diastolic phase of cardiac function is associated with lower arterial flow and hence higher concentration of intra arterially injected drug is achieved at the site of injection. it is herein postulated that drugs show higher efficacy when injected during the diastolic phase of cardiac function. it is also postulated that this benefit cannot be achieved when the drug is injected with higher rate...

Self-Boosting Vaccination In article number 2207892, Xiang Gao, Bo Liu, Jing and co-workers propose a pulsatile antigen released core-shell microparticle namely LbL/MPs to achieve self-boosting vaccination after single-injection simulate multi-injection immunization. show multiple release characteristics can effectively induce immune response. The microstructure supplies the characteristic of p...

When injected arterially, serotonin (5-hydroxytryptamine; 5-HT) has been shown to elicit naturally sized urea pulse events in the gulf toadfish, Opsanus beta. The goal of the present study was to determine which 5-HT receptor(s) was involved in mediating this serotonergic stimulation of the pulsatile excretion mechanism. Toadfish were surgically implanted with caudal arterial catheters and intr...

introduction: pulsatile injection of gnrh in hypothalamic amenorrhea is known to result in ovulation. the aim of this research was to study the effect of non pulsatile gnrh agonist administration on the ovaries of immature rats. material and methods: in this research the immature rats was divided to 7,17 and 27 daysand each were subdivided to four subgroups. subcutaneous injection every 12 hour...

Palatal myoclonus is a rare cause of pulsatile tinnitus in patients presenting to the otolaryngology office. Rhythmic involuntary contractions of the palatal muscles produce the pulsatile tinnitus in these patients. Treatment of this benign but distressing condition with anxiolytics, anticonvulsants, and surgery has been largely unsuccessful. A few investigators have obtained promising results ...

In our series, Intra‐arterial Chemotherapy (IAC) was carried out in all patients by placing the microcatheter close to the origin of the ophthalmic artery where the predominant flow of chemotherapeutic agent was guided into the ophthalmic artery and controlled by intermittent fluoroscopic screening and manual hand injection. The manual injection was pulsatile with the adequate pressure of injec...

GH circulates in the plasma partially bound with a GH-binding protein (GHBP), but the physiological significance of the GHBP and how it affects GH bioactivity in vivo is still unknown. In the present study, we took advantage of the known biological action of exogenous human (h) GH to inhibit endogenous rat (r) pulsatile GH release and examined the effect of combining hGH with recombinant hGHBP ...

Management of tinnitus generally involves educational counseling, stress reduction, and/or the use of therapeutic sound. This article focuses on therapeutic sound, which can involve three objectives: (a) producing a sense of relief from tinnitus-associated stress (using soothing sound); (b) passively diverting attention away from tinnitus by reducing contrast between tinnitus and the acoustic e...