objective(s): gastroesophageal reflux disease (gerd) is one of the most common digestive disorders that frequently lead to pulmonary complications due to gastric fluid aspiration. in the present experimental study, chronic aspiration of gastric fluid, its components and bile salts in rat lung was performed to find out the main factor(s) causing pulmonary complications of gastric fluid aspiratio...

Background & Aims: Idiopathic pulmonary fibrosis (IPF) is a chronic diffuse interstitial lung disease, which has symptoms such as coughing and shortness of breath. The average survival duration in these patients is estimated as 3 years after the onset of symptoms. Today, the therapeutic approach used in IPF cases is the usage of chemical or herbal antioxidants in order to elim...

Background: To evaluate impact of spironolactone (S) on pulmonary toxicity of concomitant use of thoracic radiotherapy (RT) and trastuzumab (T).  Materials and Methods: Eighty rats were divided into eight groups: group (G) 1 was control group; G2, G3 and G4 were RT, S and T groups; G5, G6, G7 and G8 were RT+T, T+S, RT+S and RT+T+S groups respectively. Rats were sacrificed at 6 hour, 21 and 100 ...

Objective: Pulmonary fibhrosis is a disease of the connective tissues in the respiratory system. Nigella sativa has been used for the treatment of pulmonary diseases like asthma. This study investigated the early and late preventive effect of methanolic extract of N. sativa on a bleomycin- induced pulmonary fibrosis model. Materials and Methods: This study was carried out using 52 rats. Pulmona...

Diabetes mellitus associated with oxidative stress and inflammation can affect many organs. While the effects of diabetes on organs are well known documented, its mechanisms action lung far less. 
 Hyperglycemia lead to damage by increasing stresses inflammation. may be a trigger for pulmonary fibrosis, as studies suggest that there an important link between fibrosis diabetes. In this revi...

Pulmonary fibrosis is a diverse group of lung disorders defined by varying degrees and inflammation in the pulmonary parenchyma. While it may be caused known disease, e.g., autoimmune or connective tissue disorder, drugs, hypersensitivity to inhaled organic antigens, sarcoidosis, also occurs idiopathic. When we examine pathogenesis fibrosis, see that cellular aging plays major role. Lung fibrob...

Objective(s): The role of N-acetylcysteine (NAC) as an anti-oxidant in attenuating bleomycin-induced pulmonary fibrosis has been reported. However, its effect on parenchymal remodeling via regulating the protease-antiprotease balance is not fully defined. Therefore, the present study was designed to explore the possible role of matrix metalloproteinases (MMP), tissue i...

Pulmonary Hypertension is a progressive vascular disease resulting from the tapering of pulmonary arteries causing high arterial blood pressure and ultimately right ventricular failure. A defining characteristic excessive remodeling that includes increased proliferation, fibrosis inflammation. There no outward cure for nor are there interventions effectively impede or reverse remodeling, resear...

Although several animal models have been developed to study human pulmonary fibrosis, lack of a perfect model has raised the need for various animal models of pulmonary fibrosis. In this study, we evaluated the pulmonary effect of polyhexamethyleneguanidine phosphate instillation into the lungs of mice to determine the potential of these mice as a murine model of pulmonary fibrosis. Intratrache...