the protonation of different species of glycylisoleucine were studied in the ph range of 1.5 - 10 at25 °c using potentiometric technique. investigations were performed in sodium perchlorate andtetraethylammonium iodide as background electrolytes at i (0.1, 0.2, 0.3, 0.4, 0.5, and 0.6) moldm-3. the parameters based on the protonation constants were calculated, and their dependenceson ionic stren...

In this research, the protonation constant value of tannic acid was determined at 25 °C and different ionic strengths (0.1 to 0.7 mol/dm3 NaCl) using potentiometric titration technique. The dependence of protonation constant on ionic strength was modeled and discussed by a Debye-Hückel type equation. Then, based on the obtained data from experiments, the minimizing Sum o...

protonation of the reactive intermediates generated in the raction between dalkyl acetylenedicarboxylates and triphenylphosphine by isonitrosoacetophenone leads to vinyltriphenylphosphonium salts, which undergo intramolecular wittig reaction to produce dalkyl 4-phenyl-n-hydroxypyrrole-2,3-dicarboxylates in moderate yields.

The protonation of different species of glycylisoleucine were studied in the pH range of 1.5 - 10 at25 °C using potentiometric technique. Investigations were performed in sodium perchlorate andtetraethylammonium iodide as background electrolytes at I (0.1, 0.2, 0.3, 0.4, 0.5, and 0.6) moldm-3. The parameters based on the protonation constants were calculated, and their dependenceson ionic stren...

The prtnonation constant values of tryptophan were studied at 25 C. different ionic strengths. 0.1-1.0 moldm", and various ionic media of NaCIO, and N4N01, using a combination of spectrophotometrie andpotentiometric techniques. The general vend for the two protonation con Slant Vai net of tryptophan is in theorder of NaC104 > NaNO3 in different ionic media. The dependence of protonation constan...

The protonation constant values of salicylic and 5-nitrosalicylic acid werestudied by a combinationof spectrophotometric and potentiometric methods at 25 °C in wide range of ionic strength. The ionicstrength of solutions was kept constant by sodium perchlorate as background electrolyte at 0.10 to 3.0 moldm-3. Potentiometer was calibrated according to Gran method at each of ionic strength. The p...

The protonation of the ligand molecule and the protein binding site has a significant influence on the results obtained by protein-ligand docking. Due to the inability of X-ray crystallography to resolve the hydrogen atom in protein and protein complex structures, the correct protonation for the protein and the ligand has to be assigned on a theoretical basis before the structures can be used. ...

p53 tumor suppressor gene, also known as “genome guardian” is mutated in more than half of allkind of cancers. in this study we have investigated the controls of environmental ph for p53 genemutation in point of specific sequence which is prone to mutagenesis. the most probable cancerousmutations occur as point mutations in exons 5-8 of p53 gene. the 175th codon of p53 is the thirdmost mutated ...

An explicit application of isodesmic reaction (a proton exchange between the studied and similar in structure reference molecule), where the free energy change of the protonation reaction in water was obtained using the free energies in solution from a single continuum model, was used to predict stepwise protonation constants of nitrilotriacetic acid. Calculations were performed at the RB3LYP/6...