نتایج جستجو برای: proteolipids
تعداد نتایج: 673 فیلتر نتایج به سال:
Central nervous system (CNS) myelin, the likely major target of autoimmune attack in multiple sclerosis (MS), contains a number of unique components that are potential targets of the attack. Two classes of molecules that are greatly enriched in CNS myelin compared to other parts of the body are certain types of proteolipids and glycolipids. Due to the hydrophobic nature of both of these classes...
The formation of central nervous system myelin by oligodendrocytes requires sterol synthesis and is associated with a significant enrichment of cholesterol in the myelin membrane. However, it is unknown how oligodendrocytes concentrate cholesterol above the level found in nonmyelin membranes. Here, we demonstrate a critical role for proteolipids in cholesterol accumulation. Mice lacking the mos...
Bovine white matter proteolipids have been studied by several physical methods and have been found to exist as micelles in 2: 1 (v/v) chloroform-methanol solution. The data would indicate the existence of a critical micelle concentration at 0.017-0.022 g/100 ml. The curve appears linear in the range 0.017-0.2 g/100 ml, but from the data at higher concentrations it would appear that a change in ...
The use of electrospray ionization MS to determine the structure of glycans in intact glycoproteins.
and VIIIb (I. M. Fearnley, unpublished work), and the cytochrome bc, subunit IX [16], have been recorded satisfactorily in conventional solvents containing acetonitrile or methanol, and in some cases in chloroform/methanol also [5]. However, it is not possible to record spectra of the large proteolipids such as ND2 and ATPase6 in solvents based on acetonitrile or methanol, as large hydrophobic ...
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