one of the main members of the large aggregating proteoglycans (pgs) family is versican which is able to bind to hyaluronate. versican is a chondroitin sulfate proteoglycan and is a key ingredient of the extracellular matrix.  due to its widespread expression in the body, versican is involved in cell adhesion, proliferation and migration. induced expression of versican is often observed in tiss...

The unfolding coronavirus disease 2019 (COVID-19) has increased the incidence of several dermatological disorders, including diffuse hair loss. Research revealed an escalated pattern loss (PHL) and telogen effluvium (TE) in COVID-19 patients. Psychological stress, systemic inflammation oxidative stress are potential culprits. Reduced anagenic expression proteoglycans is a mediating mechanism th...

The proteoglycans synthesized by cartilage both in vivo and in vitro have been well characterized and serve as a standard for comparison with proteoglycans from other tissues. Both cartilage and muscle are mesenchymally derived tissues; yet proteoglycans synthesized by skeletal muscle have not been studied. This report describes the isolation and preliminary characterization of skeletal muscle ...

In this editorial to MDPI Pharmaceuticals special issue "Glycosaminoglycans and Proteoglycans" we describe in outline the common structural features of glycosaminoglycans and the characteristics of proteoglycans, including the intracellular proteoglycan, serglycin, cell-surface proteoglycans, like syndecans and glypicans, and the extracellular matrix proteoglycans, like aggrecan, perlecan, and ...

Proteoglycans may modulate axon growth in the intact and injured adult mammalian CNS. Here we investigate the distribution and time course of deposition of a range of proteoglycans between 4 and 14 days following unilateral axotomy of the nigrostriatal tract in anaesthetised adult rats. Immunolabelling using a variety of antibodies was used to examine the response of heparan sulphate proteoglyc...

Purified proteoglycans from bovine nasal cartilage (the Al fraction) were separated by sedimentation velocity centrifugation into a fraction enriched in aggregates (Al-Sl) and a fraction of nonaggregated proteoglycans (Al-S2), containing about 85% and 15% of the starting material, respectively. Both fractions were centrifuged in a dissociative CsCl density gradient to remove non-proteoglycan pr...

Dermatan sulfate proteoglycans were isolated from adult bovine sclera and adult bovine articular cartilage. Their immunological relationships were studied by enzyme-linked immunosorbent assays using polyclonal antibodies raised against the large and small dermatan sulfate proteoglycans from sclera and a polyclonal and monoclonal antibody directed against the small dermatan sulfate proteoglycans...

BALB/c mice were immunised with high or low density native human cartilage proteoglycans, or the respective core proteins obtained from chondroitin ABC lyase digestion. Mice injected with high density native proteoglycans developed arthritis whereas mice injected with low density proteoglycans or with core proteins did not. Analysis of the immune response by enzyme linked immunosorbent assay (E...