نتایج جستجو برای: protein tyrosine phosphatase 1b

تعداد نتایج: 1300053  

Journal: :the journal of tehran university heart center 0
parvin pasalar biochemistry department, faculty of medicine, medical sciences / university of tehran, tehran, iran. wei qiu department of laboratory medicine & pathobiology, hospital for sick children, university of toronto, rita kohen avramoglu department of laboratory medicine & pathobiology, hospital for sick children, university of toronto, gus sidiropoulos department of laboratory medicine & pathobiology, hospital for sick children, university of toronto, khosrow adeli department of laboratory medicine & pathobiology, hospital for sick children, university of toronto,

background: the hepatic secretion of apolipoprotein b (apob), containing lipoproteins, is known to be regulated by insulin, and the overproduction of these atherogenic lipoproteins occurs in insulin-resistant states. protein tyrosine phosphatase 1b (ptp-1b) is a key regulator of hepatic insulin signaling and is also upregulated in insulin resistance. we aimed to investigate the role of ptp-1b i...

Journal: :Developmental Cell 2002

Journal: :Seminars in Cell & Developmental Biology 2015

Journal: :Coordination Chemistry Reviews 2016

Journal: :The Journal of biological chemistry 2004
Feng Gu Duc Thang Nguyên Matthew Stuible Nadia Dubé Michel L Tremblay Eric Chevet

Protein-tyrosine phosphatase 1B (PTP-1B) is the prototypic tyrosine phosphatase whose function in insulin signaling and metabolism is well established. Although the role of PTP-1B in dephosphorylating various cell surface receptor tyrosine kinases is clear, the mechanisms by which it modulates receptor function from the endoplasmic reticulum (ER) remains an enigma. Here, we provide evidence tha...

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