hydrogels are introduced to modem medicine as novel materials suitable for a variety ofbiomedical applications. studying hydrogels as novel biomaterials has become a fast-developingand exciting research field during the last two decades. these interesting biomaterials have found awide range of application including contact lenses, vehicles for drug delivery and scaffold in tissueengineering and...

the delivery of therapeutic proteins has gained momentum with development of biotechnology. however, large molecular weight, hydrophilic nature and susceptibility to harsh environment of gastrointestinal tract (git) resulted in low absorption. the main objective of this work was the design of a particulate system for oral delivery of recombinant human growth hormone (rhgh) on the basis of parti...

background and objectives: preterm labor is a serious problem in obstetrics, accounting for 70% of perinatal mortality. high sensitive c - reactive protein (hs-crp) is a sensitive marker of inflammation. our aim in this study was to determine amniotic fluid hs-crp concentration and its correlation with pre-term delivery.   materials and methods: this prospective study was conducted on 90 pregna...

objective: to investigate the clinical advantage of several prognostic factors for predicting preterm delivery. materials and methods: eighty and six patients with a singleton pregnancy admitted to vali-asr hospital underwent genetic amniocentesis between the 15th and 23th weeks were included in this study. maternal serum c-reactive protein (crp), transvaginal sonographic measurement of cervica...

Peptide and protein drugs have found an important position in therapeutics. Recent advances in pharmaceutical biotechnology have led to an increase in the number of protein products in the market. As these therapeutic proteins and peptides are made available, it will be essential to formulate these drugs into safe and effective delivery systems. The twenty different naturally occurring amin...

Peptide and protein drugs have found an important position in therapeutics. Recent advances in pharmaceutical biotechnology have led to an increase in the number of protein products in the market. As these therapeutic proteins and peptides are made available, it will be essential to formulate these drugs into safe and effective delivery systems. The twenty different naturally occurring amin...

conclusions the results indicated that sod-loaded in sln was delivered into deep burned skin layer and induced high enzyme activity through the skin. low particle size, application of lecithin as surfactant and low crystallinity index (ci) percentage were important factors for increasing sod penetration through the burned rat skin. percentage of activity by sln dispersions through rat skin was ...

background and objectives: baculovirus can be used as a vector in gene delivery system. viral envelope of baculovirus would display expressed protein/peptide and it could render as a potential vaccine delivery system. in this regard, the gene coding for a subunit of shiga toxin (stxa) from escherichia coli ( e. coli ) strain was cloned in a baculovirus expression system. stxa subunit has the ab...

protein status of 194 pregnant women and their newborn at a public and a private maternity hospital in tehran was studied. blood samples were taken from all women before delivery and from cords at delivery of the placenta. the following determinations were made: total serum protein, protein fractions, creatinine and urea. in the private group, significantly higher maternal mean values were foun...