results like other cancers, prostate cancer is caused by an accumulation of genetic alterations in a cell that drives it to malignant growth. specific genes and gene alterations have been suggested to play a role in its development and progression. aneuploidy, loss of heterozygosity, gene mutations, hypermethylation and inactivation of specific tumour suppressor genes such as gstpi, apc, mdr1, ...

background: presence of discordance between the gleason score on needle biopsy and the score of radical prostatectomy specimen is common and universal. in this study, we determined the accuracy of gleason grading of biopsies in predicting histological grading of radical prostatectomy specimens and the degree of overgrading and undergrading of prostatic adenocarcinoma in our center, which is one...

prostate cancer is a major cause of morbidity and mortality in iran, yet there are few studies examining risk factors specific to the iranian context. we conducted a case-control study to explore risk factors for prostate cancer in mazandaran, iran from 2005 to 2008. the cases were 137 men with clinicopathologically confirmed prostate cancer. controls were 137 neighborhood and age match men wit...

BACKGROUND Uro-oncological neoplasms have both a high incidence and mortality rate and are therefore a major public health problem. The aim of this study was to evaluate research activity in uro-oncology over the last decade. METHODS We searched MEDLINE and ClinicalTrials.gov systematically for studies on prostatic, urinary bladder, kidney, and testicular neoplasms. The increase in newly publ...

conclusions using tzpsad as an adjunct to psa may improve the specificity of psa in the diagnosis of pca and decrease the number of unnecessary prostatic biopsies in iranian men with serum psa level < 20 ng/ml. results among 1120 men who were eligible for enrolment, prostate cancer was detected in 265 patients. mean serum psa levels were 9.7 ± 4.3 ng/ml and 8.5 ± 3.7 ng/ml in patients with and ...

background: recently, the development of new biomarkers as prognostic and predictive markers in prostate cancer has been crucial. objectives: this study was aimed to determine whether serum vascular endothelial growth factor (vegf) levels would be a prognostic marker or risk assessment factor in patients with prostate cancer and to investigate whether it could differentiate cancerous tissue fro...

Neuroendocrine differentiation in prostatic carcinomas generally confers a more aggressive clinical behavior and less favorable prognosis than usual prostatic carcinomas. In this manuscript, we report a case of a 58-year-old man with prostatic carcinoma who died 1 year after initial diagnosis. Autopsy showed a disseminated prostatic carcinoma with neuroendocrine differentiation. There were meta...

background: the presence of noncutaneous neoplasms does not seem to increase the risk of cutaneous malignant melanoma; however, it seems to be associated with the development of other hematological, brain, breast, uterine, and prostatic neoplasms. an ecological transversal study was conducted to study the geographic association between cutaneous malignant melanoma and 24 localizations of cancer...