objective(s): prostaglandins have been shown to mediate the gastro-protective effect of sodium hydrosulfide (nahs) but effect of nahs on mrna expression of prostaglandin e2 receptors (ep1, 3-4; eps) has not been investigated. therefore, this study designed to evaluate the effect of nahs on mrna expression of eps receptors in response to mucosal acidification and distention-induced gastric acid ...

in this paper a general discussion of the available data on the role of prostaglandin (pg) and phosphodiesterase is discussed. functional studies would be a next step to understand the functional meaning of the data described in this paper. the data presented are a basis for further research on selective modulation of the ep1 and ep2 receptor which could be a therapeutic target in functional bl...

Receptors for prostaglandin E2 or histamine were measured on subpopulations of human lymphocytes, using the cyclic AMP increase after exposure to prostaglandin or histamine as an indicator for the presence of receptors. The cyclic AMP response to prostaglandin E2 was similar in unfractionated lymphocytes and the T-enriched and T-depleted fractions. Within the T-enriched population, T cells bear...

statement of the problem: a major objective of investigators is to clarify the role of metabolites in achievement of maximum tooth movement with minimal root damage during orthodontic tooth movement (otm). purpose: the aim of this study was to determine the effect of administration of thyroid hormone, prostaglandin e2, and calcium on orthodontic tooth movement and root resorption in rats. mater...

The present study was designed to observe the protective effect and mechanisms of meloxicam on liver injury caused by chronic aluminium exposure in rats. The histopathology was detected by hematoxylin-eosin staining. The levels of prostaglandin E2, cyclic adenosine monophosphate and inflammatory cytokines were detected by enzyme linked immunosorbent assay. The expressions of cyclooxygenases-2, ...

BackgroundChronic rhinosinusitis (CRS) can be divided into endotypes by functional or pathophysiologic findings.ObjectiveThe aim of this study was to analyze the expression cytokines, prostaglandin (PG) synthases, and their receptors related pathogenesis CRS, especially those contributing nasal polyp (NP) formation.MethodsNPs uncinate tissue (UT) samples were collected from 90 patients who unde...

246 words Introduction: 534 words Discussion: 2209 words Abbreviations: COX, cyclooxygenase; COX-2, cyclooxygenase-2; TBS, tris-buffered saline; P-gp, P-glycoprotein; BBB, blood-brain barrier; PGE2, Prostaglandin E2; EEG, Electroencephalogram; NMDA, N-methyl-D-aspartic acid; CNS, central nervous system Section: Neuropharmacology This article has not been copyedited and formatted. The final vers...