In order to clarify the role of prostacyclin-thromboxane system (PTS) in development acute circulatory disorders early postoperative period after coronary artery bypass surgery, its condition was studied 86 patients with disease. vascular insufficiency and shock, a decrease level thromboxane blood revealed, while arterial hypertension, elevated concentrations were determined absence changes pro...

background: study of vascular and its secretory profile changes is an important issue in pathogenesis of radiation myelopathy. this paper reports the prostacyclin concentration changes after low-moderate doses of x-irradiation within a short period of time. materials and methods: cervical cords of wistar rats were irradiated to doses of 0.5, 1, 2, 4 and 6 gy x-rays. after 24 hours, 2 and 13 wee...

Background: Study of vascular and its secretory profile changes is an important issue in pathogenesis of radiation myelopathy. This paper reports the prostacyclin concentration changes after low-moderate doses of X-irradiation within a short period of time. Materials and Methods: Cervical cords of Wistar rats were irradiated to doses of 0.5, 1, 2, 4 and 6 Gy X-rays. After 24 hours, 2 and 13 ...

Because deformation of lung tissue stimulates prostaglandin synthesis, we wanted to investigate whether hydrodynamic forces would affect lung prostacyclin (PGI2) production. To test the hypothesis that lung prostacyclin synthesis was flow dependent, we examined lung prostacyclin production after flow alterations. Using a salt solution that contained either Ficoll or albumin as a perfusate, we c...

BACKGROUND Prostacyclin elicits a potent vasodilation and inhibition of platelet aggregation through binding to its membrane receptor. The impairment of prostacyclin receptor activity is implicated in various human cardiovascular diseases. In the present study, we succeeded in the isolation and characterization of human prostacyclin receptor cDNA and elucidated its gene expression in human tiss...

Prostacyclin is a powerful vasodilator and inhibitor of platelet aggregation that has been implicated to play a role in cerebrovascular disease. Prostacyclin is unstable in aqueous solution and stabilized in serum by binding to an unidentified serum protein as measured by gel filtration. In 15 patients with ischemic stroke we measured the serum prostacyclin binding capacity and the rate of degr...

Prostacyclin (PGI2) plays important roles in hemostasis both as a vasodilator and an endogenous inhibitor of platelet aggregation. PGI2 functions in these roles through a specific IP receptor, a G protein-coupled receptor linked to Gs and increases in cAMP. Here, we report that intracellular prostacyclin formed by expressing prostacyclin synthase in human embryonic kidney 293 cells promotes apo...

By use of several prostacyclin analogs and an in vitro autoradiographic technique, we have found a novel subtype of the prostacyclin receptor, one having different binding properties compared with those of the known prostacyclin receptor in the rat brain. Isocarbacyclin, which is a potent agonist for the known prostacyclin receptor, had high affinity for the novel subtype (dissociation constant...

Prostacyclin is a powerful cardioprotective hormone released by the endothelium of all blood vessels. Prostacyclin exists in equilibrium with other vasoactive hormones and a disturbance in the balance of these factors leads to cardiovascular disease including pulmonary arterial hypertension. Since it's discovery in the 1970s concerted efforts have been made to make the best therapeutic utility ...