نتایج جستجو برای: propoxy
تعداد نتایج: 252 فیلتر نتایج به سال:
In a search towards new and efficient agents to treat mental disorders such as schizophrenia 6-[3-(4-substitutedphenylpiperazin-1-l)propoxy]benzo[d][1,3]oxathiol-2ones were designed, synthesized and evaluated in vivo for their ability to inhibit apomorphine induced climbing behaviour and inhibition of 5-HTP induced head twitches representing antidopaminergic and antiserotonergic action respecti...
To reduce volumetric shrinkage of the commercially available polymeric dental composite during curing reaction, (2,2-bis [4-(2-hydroxy-3-methacryloyloxy propoxy) phenyl] propane) (bis-GMA) derivatives, i.e., (2,2-bis[3-methyl, 4-(2-hydroxy-3-methacryloyloxy propoxy) phenyl] propan) (DMBis-GMA) and (2,2bis[3,5-dimethyl, 4-(2-hydroxy-3-methacryloyloxy propoxy) phenyl] propane) (TMBis-GMA) were sy...
The metabolism and pharmacokinetics of gefitinib (Iressa®, N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholino-propoxy)quinazolin-4-amine), a selective thymidylate kinase inhibitor for the epider...
Dispersed fluorescence (DF) spectra of 1-propoxy, 1-butoxy, 2-propoxy, and 2-butoxy radicals have been observed under supersonic jet cooling conditions by pumping different vibronic bands of the B-X laser induced fluorescence excitation spectrum. The DF spectra were recorded for both conformers of 1-propoxy, three conformers of the possible five of 1-butoxy, the one possible conformer of 2-prop...
On the basis of N-((5-(3-(1-benzylpiperidin-4-yl)propoxy)-1-methyl-1H-indol-2-yl)methyl)-N-methylprop-2-yn-1-amine (II, ASS234) and QSAR predictions, in this work we have designed, synthesized, and evaluated a number of new indole derivatives from which we have identified N-methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine (2, MBA236) as ...
Iloperidone, [1-[4-[3-[4-(6-fluoro-1, 2-benzisoxazol-3-yl)-1-piperidinyl]propoxy]-3-methoxyphenyl]eth anone, 1, is currently undergoing clinical trials as a potential antipsychotic agent. The metabolism of iloperidone was studied in human liver microsomes to define the metabolic pathways and to identify the cytochrome P450 (CYP) isoforms responsible for the formation of major iloperidone metabo...
A decalin gel consisting of a 3,3'-bis[{(octylamino)carbonyl}propoxy]azobenzene derivative with H-aggregation showed a photon-density dependent E-Z isomerization, indicating the cooperating isomerization of each module.
The potential of selected microorganisms to O-dealkylate alkyl aryl ethers in a manner analogous to mammalian systems has been studied. A total of 45 fungi and actinomycetes were screened for their ability to O-demethylate 4-methoxybiphenyl. Of the 20 organisms found to actively metabolize this substrate, 5 were chosen for additional study. Incubation with a series of five homologous 4-alkoxybi...
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