نتایج جستجو برای: prophylactic total gastrectomy
تعداد نتایج: 825345 فیلتر نتایج به سال:
absract gastric cancer is the fourth most common cancer and the second leading cause of cancer death. most cases are sporadic and only 10% of patients, show familial clustering. among these patients, 1 to 3 % have hereditary diffuse gastric cancer (hdgc), which is autosomal-dominant and present in younger ages. mutations in ecadherin gene cdh1 has been identified in 30 to 50% of patients. becau...
BACKGROUND Germline mutation of the CDH1 gene, which encodes for the E-cadherin adhesion protein, is rare but confers an estimated lifetime risk of hereditary diffuse gastric cancer of 87%. Fewer than 100 prophylactic total gastrectomies have been reported for this condition. METHODS Patients with germline CDH1 mutation who underwent multidisciplinary counseling followed by prophylactic total...
Hereditary diffuse gastric cancer (HDGC) is characterized as an autosomal dominant cancer susceptibility syndrome largely attributable to germline mutations and deletions in the gene encoding E-cadherin, CDH1. Mutation carriers have a more than 70% lifetime risk of developing DGC and an elevated probability of lobular breast cancer. The aim of this review was to evaluate the results of surgical...
BACKGROUND Ten percent of gastric cancer (GC) cases are familial, with one third resulting from a mutation in the tumor suppressor gene CDH1. Loss of this important structure can result in hereditary diffuse gastric cancer (HDGC), which carries a high mortality if early diagnosis is not made. Despite its clear genetic origin, optimal management of HDGC family members is controversial, as the ut...
Abstract Background Prophylactic use of abdominal drain in gastrectomy has been questioned the last 15 years, and a 2015 Cochrane meta-analysis on four RCTs concluded that there was no convincing evidence to routine placement gastrectomy. Nevertheless, authors evidenced moderate/low quality included studies highlighted how 3 out 4 came from Eastern countries. After 2015, only retrospective have...
OBJECTIVE The aim of this study was to describe postoperative outcomes of total gastrectomy at our institution for patients with hereditary diffuse gastric cancer (HDGC). BACKGROUND HDGC, which is mainly caused by germline mutations in the E-cadherin gene (CDH1), renders a lifetime risk of gastric cancer of up to 70%, prompting a recommendation for prophylactic total gastrectomy. METHODS A ...
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