multicentric reticulohistiocytosis (mrh) is a rare proliferative histiocytic disease of ‎unknown cause with potentially disabling nature. primary manifestations are involvement ‎of skin and joints. the articular destruction can lead to permanent joint deformities. our ‎patient was a 47 year-old woman with bilateral symmetrical polyarthritis and reddish- ‎brown papulonodular cutaneous lesions. t...

Langerhans cell histiocytosis (LCH) belongs to histiocytic proliferative diseases, which are rare in clinical practice; however they pose significant challenges both for their diagnosis and choice of therapeutic strategies. Histiocytic diseases the scope oncology; nevertheless, at diagnostic stage patients referred pediatricians or dermatologists. That is why interdisciplinary interaction vario...

RDD (Rosai Dorfman disease) is a rare and benign histiocytic proliferative disorder of unknown etiology. FNAC (Fine-needle aspiration cytology) is a useful and reliable tool for the diagnosis of RDD, and as such, biopsy is avoidable.

INTRODUCTION Langerhans' cell histiocytosis is a proliferative histiocytic disorder of unknown cause originating from dendritic cells. CASE PRESENTATION The authors report a case of Langerhans' cell histiocytosis in a 48-year-old man with multisystemic disease presentation, including liver involvement. CONCLUSION Hepatic involvement is an uncommon feature in this rare disease and there is n...

Canine histiocytic proliferative disorders include a wide spectrum of diseases characterized by different biologic behaviors. The etiology and pathogenesis of these diseases are largely unknown. The clinicopathologic, morphologic and immunophenotypic characteristics of canine localized and disseminated histiocytic sarcoma were examined in 39 dogs. Rottweilers, Bernese Mountain Dogs, and retriev...

Histiocytoses describe a diverse group of proliferative disorders involving dentritic cells and macrophages. They include a spectrum of diseases including a reactive inflammatory accumulation of cells, pathologic immune activation, or neoplastic clonal proliferation. Advanced molecular technologies are resulting in new breakthroughs in understanding the pathophysiology of histiocytic disorders ...

Successful Treatment of Rosai-DorfmanDisease With Low-DoseOral Thalidomide Rosai–Dorfman disease (RDD) is a rare idiopathic histiocytic proliferative disorder.1 The skin is the most frequently involved extranodal organ. Nevertheless, primary cutaneous manifestation of RDD (CRDD) without systemic involvement is rare.2 We present herein a case of CRDD showing excellent remission after low-dose or...

Rosai-Dorfman disease is a rare, benign histiocytic proliferative disorder that usually affects the lymph nodes. Although extranodal involvement has been reported in diverse sites, manifestation in the cardiovascular system is extremely rare. Specifically, cardiac involvement in Rosai-Dorfman disease is an extraordinarily infrequent event. We describe a case of a 36-year-old female who presente...

Rosai-Dorfman disease is a rare histiocytic proliferative disorder that commonly presents with a massive lymphadenopathy and a variety of constitutional symptoms. Severe hemolytic anemia is an infrequent complication of this disease. Although the etiology of the condition is unknown, infectious agents including viruses have been implicated. We describe a 2-year-old female child who presented wi...