one of the most important problems in neuroscience researches is the understanding what is the communication between the immune system and central nervous system. proinflammatory factors play an important role in this communication. the dysregulation of proinflammatory factors such as cytokines and chemokines is a central feature in the development of neuroinflammation.one of the important  cyt...

background: receptor for advanced glycation end products (rage) plays a causative role in diabetes. garlic (allium sativum) belongs to compounds with anti-glycation activity that can be considered as probable therapeutic approaches in delaying or preventing the onset of diabetes complications. the aim of this study was to evaluate the influence of garlic on the rage expression and proinflammato...

results aβ (1-42) stimulated the production of the proinflammatory cytokines il6, il1β, tnfα, and il18 in both the primary microglia cell culture and the b92 cell line. both the raav-il4 construct and the ril-4 protein were found to inhibit production of the most important aβ (1-42)-induced proinflammatory cytokine mrnas in the two types of cells with different patterns. conclusions it seems th...

aim: was to assess the effects of ramadan observance upon repeated sprints and associated inflammatory and oxidative stress responses. methods: ten young trained boxers were tested during a control period (c), at the end of the first week (r-1), and during the fourth week of ramadan observance (r-4). on each occasion, they performed three vertical jumps, 10 x 6 s repeated sprints on a cycle erg...

Introduction: Following a traumatic brain injury (TBI), the excessive release of proinflammatory cytokines is major cause of cerebral edema that can cause permanent neuronal loss. This study examined the changes in brain concentrations of proinflammatory cytokines IL-1, IL-6, TNF-α and TGF- after different doses of estrogen or progesterone treatment in brain-injured rats at 6 and 24 h post...

extra-cellular levels (serum) of heat shock protein 70 is influenced by various stressors such as exercise and it has been shown that this protein affects the proinflammatory cytokines in human and animal samples. the aim of this study was to investigate the effect of endurance training on serum levels of proinflammatory cytokines (tnf-?, il-1?, il-6 and hsp70) in trained and untrained rats. fo...

Introduction: Based on human studies, inequality and social injustice have adverse effects on the individual and community health. In this study, the effects of food intake inequality and social status changes on pain perception and immunological factors were investigated in Balb/C mice. Methods: The present study was conducted by implementing different social stresses including food depriva...