objective(s): breast cancer is the most common type of cancer among women worldwide. this study investigated the expression and clinical significance of activating transcription factor 3 (atf3) in human breast cancer and its relationship with the clinical outcome of breast cancer.   materials and methods : atf3 expressions were detected in 114 primary breast cancer tissues and 114 adjacent norm...

A major goal in translational cancer research is to identify biological signatures driving cancer progression and metastasis. A common technique applied in genomics research is to cluster patients using gene expression data from a candidate prognostic gene set, and if the resulting clusters show statistically significant outcome stratification, to associate the gene set with prognosis, suggesti...

Background: Circulating adiponectin levels are inversely correlated with the risk of colorectal cancer (CRC). This study was designed to evaluate the association between adiponectin levels and the clinicopathological variables of CRC and to analyze the possible prognostic value of adiponectin in predicting relapse-free survival. Patients and Methods: Baseline adiponectin and serum tumor markers...

An index of severity of coronary artery disease is described which takes into account the site, severicy and number of ali iesions in the coronary arreries. A percentage figure is computed with low percentages indicating severe disease. Ten year follow-ip for 1050 medi caliy treated patients are given. During che period of observation the overali mortaiity rate was 6.3%. 68% of deaths occurring...

Several studies have demonstrated a strong association between coronary vascular endothelial dysfunction and an adverse long-term cardiovascular prognosis. Both conduit arterial and microcirculatory endothelial function are predictive of outcome, independent of the presence of coronary artery disease and its risk factors. Thus assessment of endothelial function or its markers in patients with d...

The clinical approach to the patient with nonsustained ventricular tachycardia (NSVT) should always be considered within the particular clinical context in which the arrhythmia occurs. In the documented absence of heart disease, spontaneous NSVT does not carry any adverse prognostic significance. Exercise-induced NSVT may predict increased cardiac mortality. In ischaemic patients with a left ve...