Metastatic cancer may be treated either by excision of endocrine glands (surgical deprivation) or administration of hormones (addition therapy). This article deals only with deprivation. Addition will only be considered as it directly affects deprivation and not as a method of therapy in its own right. The purpose of surgical deprivation is to terminate the production of the specific hormones e...

Metastatic cancer may be treated either by excision of endocrine glands (surgical deprivation) or administration of hormones (addition therapy). This article deals only with deprivation. Addition will only be considered as it directly affects deprivation and not as a method of therapy in its own right. The purpose of surgical deprivation is to terminate the production of the specific hormones e...

E STRUS and ovulation in gilts have been successfully inhibited by daily injections of progesterone (Ulberg et al., 1951; Baker et al., 1954) and more recently by the inclusion of progestational compounds in the feed (Nellor, 1960; Dzuik and Baker, 1962). The successful use of orally active progestational agents to synchronize the estrous cycles of gilts without a subsequent reduction in fertil...

BACKGROUND Use of menopausal hormonal therapy (MHT)-containing estrogen and a synthetic progestin is associated with an increased risk of breast cancer. It is unclear if progesterone in combination with estrogen carries a lower risk of breast cancer. Limited data suggest differences between progesterone and progestins on cardiovascular risk factors, including cholesterol and glucose metabolism....

OBJECTIVE To perform an updated systematic review with meta-analysis to further elucidate the efficacy of progestational agents for the prevention of preterm births in patients at elevated risk. DATA SOURCES Computerized databases, references in published studies, and textbook chapters in all languages were used to identify randomized controlled trials (RCTs) evaluating the use of progestatio...

OBJECTIVE This study was undertaken to determine whether progestational agents, initiated in the second trimester of pregnancy, reduce the risk of delivery less than 37 weeks, among women at increased risk of spontaneous preterm birth. STUDY DESIGN Medline, pre-Medline, EMBASE, and Cochrane Central Register of Controlled Trials were searched. Randomized controlled trials with less than 20% lo...

Trans-anethole was studied for antifertility activity in rats at dose levels of 50 mg, 70 mg and 80 mg/kg po. Dose-dependent activity was observed, a 100% anti-implantation activity being achieved at 80 mg/kg, po. The compound showed a significant estrogenic activity and did not possess anti-estrogenic, progestational, anti-progestational, androgenic or anti-androgenic activities. In an earlier...

Evidence for the endocrine r81e of the human placenta has been indicat’ed by manifold physiological experiments; the supporting data for this concept have been reviewed by Newton (1). Lipide extracts of human placenta have been shown to contain progestational activity as determined by the rabbit assay method (2-4). Since the progestational hormone has not been isolated from the placental extrac...

Cystic endometrial hyperplasia-pyometra complex is the most frequent and important endometrial disorder encountered in bitches. The pathogenesis of the disease is related to the activity of progesterone [Feldman and Nelson, Canine and Feline Endocrinology and Reproduction (1996) W.B. Saunders, Philadelphia]. Cystic endometrial hyperplasia (CEH) is an abnormal response of the bitch's uterus to o...