نتایج جستجو برای: prnp

تعداد نتایج: 934  

Journal: :The Journal of general virology 2003
Yuko Nakamura Akikazu Sakudo Keiichi Saeki Tomomi Kaneko Yoshitsugu Matsumoto Antonio Toniolo Shigeyoshi Itohara Takashi Onodera

The susceptibility of prion protein gene (Prnp)-null cells to coxsackievirus B3 (CVB3) was investigated. Primary cultures of murine Prnp(-/-) brain cells were more sensitive to CVBs than corresponding cells from wild-type mice. The viral susceptibility of a Prnp-null cell line (HpL3-4) derived from the murine hippocampus was compared with that of two established cell lines (HeLa and HEp-2) that...

2011
Alberto Miranda Eva Pericuesta Miguel Ángel Ramírez Alfonso Gutierrez-Adan

Cellular prion protein (PRNP) is a glycoprotein involved in the pathogenesis of transmissible spongiform encephalopathies (TSEs). Although the physiological function of PRNP is largely unknown, its key role in prion infection has been extensively documented. This study examines the functionality of PRNP during the course of embryoid body (EB) differentiation in mouse Prnp-null (KO) and WT embry...

Journal: :Journal of medical genetics 2006
C Vollmert O Windl W Xiang A Rosenberger I Zerr H-E Wichmann H Bickeböller T Illig H A Kretzschmar

BACKGROUND A single nucleotide polymorphism (SNP) in the coding region of the prion protein gene (PRNP) at codon 129 has been repeatedly shown to be an associated factor to sporadic Creutzfeldt-Jakob disease (sCJD), but additional major predisposing DNA variants for sCJD are still unknown. Several previous studies focused on the characterisation of polymorphisms in PRNP and the prion-like doppe...

Journal: :Biochemical and biophysical research communications 2009
A G Gossner N Bennet N Hunter J Hopkins

The central role for PrP in the pathogenesis of the transmissible spongiform encephalopathies (TSEs) is illustrated by the resistance of Prnp(0/0) mice to disease and by the inverse association of Prnp gene dosage with incubation period. Understanding the role of PrP(C) in TSEs necessitates knowledge of expression levels of the Prnp gene during the development of disease. SSBP/1 scrapie shows a...

Journal: :Journal of applied genetics 2003
Krzysztof Walawski Urszula Czarnik

The study was carried out in a Polish Black-and-White cattle population, represented by 167 AI sires, 200 young tested bulls, 190 bull-dams, and 606 randomly chosen cows from commercial herds. The fragment of the bovine prion protein gene (PRNP) coding the octapeptide-repeat sequence, was identified by PCR analysis. Two different gene variants of 349 bp and 373 bp in size, produced three genoty...

2004
Jonathan D.F. Wadsworth Emmanuel A. Asante Melanie Desbruslais Jacqueline M. Linehan Susan Joiner Ian Gowland Julie Welch Lisa Stone Sarah E. Lloyd Andrew F. Hill Sebastian Brandner John Collinge

Materials and Methods Transgenic mice. Transgenic mice homozygous for a human PrP 129V transgene array and murine PrP null alleles (Prnp) designated Tg(HuPrP129V Prnp)-152 mice (129VV Tg152 mice) and transgenic mice homozygous for a human PrP 129M transgene array and murine PrP null alleles (Prnp) designated Tg(HuPrP129M Prnp)-35 mice (129MM Tg35 mice) have been described previously (S1-S4). In...

2015
Lisa Gasperini Elisa Meneghetti Beatrice Pastore Federico Benetti Giuseppe Legname

AIMS Several neurodegenerative disorders show alterations in glutamatergic synapses and increased susceptibility to excitotoxicity. Mounting evidence suggests a central role for the cellular prion protein (PrP(C)) in neuroprotection. Therefore, the loss of PrP(C) function occurring in prion disorders may contribute to the disease progression and neurodegeneration. Indeed, PrP(C) modulates N-met...

Journal: :Animal genetics 2010
P Mesquita M Batista M R Marques I C Santos J Pimenta M Silva Pereira I Carolino F Santos Silva M C Oliveira Sousa L T Gama C M Fontes A E M Horta J A M Prates R M Pereira

The establishment of an association between prion protein gene (PRNP) polymorphisms and scrapie susceptibility in sheep has enabled the development of breeding programmes to increase scrapie resistance in the European Union. Intense selection for PRNP genotype may lead to correlated selection for genes linked to PRNP. We intended to investigate if any association exists between genetic variatio...

Journal: :The Journal of heredity 2007
Christopher M Seabury Clare A Gill Joe W Templeton Joseph B Dyar James N Derr David L Adelson Elaine Owens Donald S Davis Duane C Kraemer James E Womack

Chronic wasting disease (CWD) is a transmissible spongiform encephalopathy (TSE) affecting deer (Odocoileus spp.), moose (Alces alces), and Rocky Mountain elk (Cervus elaphus nelsoni). Leucine homozygosity at elk PRNP codon 132 has been associated with reduced CWD susceptibility. However, naturally acquired CWD has been detected in elk possessing the 132 Leu/Leu genotype. Recent human and bovin...

2014
Akikazu Sakudo Takashi Onodera

Elucidation of prion protein (PrP) functions is crucial to fully understand prion diseases. A major approach to studying PrP functions is the use of PrP gene-knockout (Prnp (-/-)) mice. So far, six types of Prnp (-/-) mice have been generated, demonstrating the promiscuous functions of PrP. Recently, other PrP family members, such as Doppel and Shadoo, have been found. However, information obta...

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