نتایج جستجو برای: prions

تعداد نتایج: 4608  

Journal: :Nature Reviews Neuroscience 2003

Journal: :Diagnostic histopathology 2022

Prions are considered the prototype of transmissible proteopathies, and this property has for many decades been unique. More recently transmissibility other misfolded proteins, notably Aβ, tau synuclein, recognized. Initially, transmission these proteins was shown experimentally but relevance humans debated. The co-transmission Aβ with prions through medical procedures involving preparations de...

Journal: :PLoS Pathogens 2008
Kurt Giles David V. Glidden Robyn Beckwith Rose Seoanes David Peretz Stephen J. DeArmond Stanley B. Prusiner

Distinct prion strains often exhibit different incubation periods and patterns of neuropathological lesions. Strain characteristics are generally retained upon intraspecies transmission, but may change on transmission to another species. We investigated the inactivation of two related prions strains: BSE prions from cattle and mouse-passaged BSE prions, termed 301V. Inactivation was manipulated...

Journal: :International journal of orofacial biology 2022

The oral cavity is particularly susceptible to viral infections because of its conformation, soft tissue and salivary glands. Several viruses, including herpes simplex virus (HSV) human papillomavirus (HPV), are associated with disease-causing primary lesions. Prions smaller than viruses can only be seen through an electron microscope when they have aggregated formed a cluster. also unique in t...

Journal: :Journal of virology 2005
Michael R Scott David Peretz Hoang-Oanh B Nguyen Stephen J Dearmond Stanley B Prusiner

Transgenic (Tg) mice expressing full-length bovine prion protein (BoPrP) serially propagate bovine spongiform encephalopathy (BSE) prions without posing a transmission barrier. These mice also posed no transmission barrier for Suffolk sheep scrapie prions, suggesting that cattle may be highly susceptible to some sheep scrapie strains. Tg(BoPrP) mice were also found to be susceptible to prions f...

Journal: :Cell 1990
S B Prusiner M Scott D Foster K M Pan D Groth C Mirenda M Torchia S L Yang D Serban G A Carlson

Transgenic (Tg) mice expressing both Syrian hamster (Ha) and mouse (Mo) prion protein (PrP) genes were used to probe the mechanism of scrapie prion replication. Four Tg lines expressing HaPrP exhibited distinct incubation times ranging from 48 to 277 days, which correlated inversely with HaPrP mRNA and HaPrPC. Bioassays of Tg brain extracts showed that the prion inoculum dictates which prions a...

Journal: :Proceedings of the National Academy of Sciences 1998

Journal: :Molecular cell 2006
James Shorter Susan Lindquist

Yeast prions are protein-based genetic elements that self-perpetuate changes in protein conformation and function. A protein-remodeling factor, Hsp104, controls the inheritance of several yeast prions, including those formed by Sup35 and Ure2. Perplexingly, deletion of Hsp104 eliminates Sup35 and Ure2 prions, whereas overexpression of Hsp104 purges cells of Sup35 prions, but not Ure2 prions. He...

Journal: :Annual review of microbiology 2002
Susan M Uptain Susan Lindquist

Fungal prions are fascinating protein-based genetic elements. They alter cellular phenotypes through self-perpetuating changes in protein conformation and are cytoplasmically partitioned from mother cell to daughter. The four prions of Saccharomyces cerevisiae and Podospora anserina affect diverse biological processes: translational termination, nitrogen regulation, inducibility of other prions...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2002
Patrick J Bosque Chongsuk Ryou Glenn Telling David Peretz Giuseppe Legname Stephen J DeArmond Stanley B Prusiner

Considerable evidence argues that consumption of beef products from cattle infected with bovine spongiform encephalopathy (BSE) prions causes new variant Creutzfeldt-Jakob disease. In an effort to prevent new variant Creutzfeldt-Jakob disease, certain "specified offals," including neural and lymphatic tissues, thought to contain high titers of prions have been excluded from foods destined for h...

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