L’opera con il titolo Dell’eccellenza della donna è un discorso che Hercole Filogenio scrisse nel 1589 e dedicò a Flavia Peretti Orsina, una distinta sua epoca dotata di uno spirito inquieto i suoi interessi contribuì allo sviluppo società in cui viveva. Con suo testo l’autore scelse allinearsi “all’opinione coloro si sforzano scoprire l’errore molti, quali tanto affannano avilire feminil sesso...

Activation of the coagulation system is a fundamental host defense mechanism. Microorganisms that have invaded the body are trapped and disposed of in clots. Monocytes/macrophages are widely accepted as the main players in the procoagulant process; however, recent evidence suggests that neutrophils also play important roles. Tissue factor, which initiates the extrinsic coagulation cascade, is r...

This review focuses on the mechanisms of DNA methylation, DNA methylation pattern formation and their involvement in gene regulation. Association of DNA methylation with imprinting, embryonic development and human diseases is discussed. Furthermore, besides considering changes in DNA methylation as mechanisms of disease, the role of epigenetics in general and DNA methylation in particular in tr...

In normal myocardium, acute -adrenergic stimulation augments both systolic and diastolic performance via protein kinase A (PKA)–mediated phosphorylation of key proteins governing Ca handling and the contractile machinery. Twenty-five years ago Kranias and Solaro identified troponin I (TnI) and phospholamban (PLN) as the 2 major cardiac proteins which were nearly simultaneously phosphorylated by...