background and aims: the aim of this study was the modeling of the incidence rates of colorectal, breast and prostate cancers using a shared component model in order to explore the spatial pattern of their shared risk factors (i.e., obesity and low physical activity) affecting on cancer incidence, and also to estimate the relative weight of these shared components. methods: in this study, the ...

background: in view of high prevalence of gi cancers in lorestan province, western iran, and a large number of esophageal cancer patients in this region, this study was done to determine the frequency of various gi cancers in the area. â  methods: in a cross-sectional study, all patients from lorestan province for whom endoscoppy and colonoscopy were performed and biopsy was provided entered ou...

Background: The aim of this study was to model the geographical variation in incidence and risk factors of seven prevalent cancers in Iran. Methods: The data for cancers of esophagus, stomach, bladder, colorectal, lung, prostate, and female breast along with their risk factors in all 30 provinces of Iran for the year 2007 were included into study. Smoking, overweight, inadequate consumption of ...

Phosphorylation of proteins on serine or threonine residues preceding proline (pSer/Thr-Pro) is a major regulatory mechanism in cell proliferation and transformation. Interestingly, the pSer/Thr-Pro motifs in proteins exist in two distinct cis and trans conformations, whose conversion rate is normally reduced on phosphorylation, but is catalyzed specifically by the prolyl isomerase Pin1. Pin1 c...

Mutations 1 295 228 C>T and 1 295 250 C>T (termed C228T and C250T respectively), corresponding to -124 C>T and -146 C>T from the translation start site in the promoter of the telomerase reverse transcriptase (TERT) gene, have recently been reported in human cancers, but not in thyroid cancers yet. We explored these mutations in thyroid cancers by genomic sequencing of a large number of primary ...