background: excess serum uric acid (ua) accumulation can lead to various diseases. increasing evidences reveal that ua may have a key role in the pathogenesis of metabolic syndrome. little is known about the associations of ua levels with cardiometabolic risk factors in prediabetic individuals. this study was designed to evaluate the association between ua and cardiometabolic risk factors in pr...

BACKGROUND Excess serum uric acid (UA) accumulation can lead to various diseases. Increasing evidences reveal that UA may have a key role in the pathogenesis of metabolic syndrome. Little is known about the associations of UA levels with cardiometabolic risk factors in prediabetic individuals. This study was designed to evaluate the association between UA and cardiometabolic risk factors in pre...

BACKGROUND Elevated levels of proinflammatory proteins are predictive of both cardiovascular (CV) disease and type 2 diabetes. Previously, atherogenic changes in traditional CV risk factors in the prediabetic state were mainly seen in insulin-resistant subjects rather than in those with a predominant defect in insulin secretion. METHODS AND RESULTS We studied in prediabetic individuals from t...

Gap junctional intercellular communication between β-cells is crucial for proper insulin biosynthesis and secretion. The aim of this work was to investigate the expression of connexin (Cx)36 at the protein level as well as the function and structure of gap junctions (GJ) made by this protein in the endocrine pancreas of prediabetic mice. C57BL/6 mice were fed a high-fat (HF) or regular chow die...

BACKGROUND Dyslipidemia occurring in diabetic patients, play a critical role in acceleration of macrovascular atherosclerosis and contribute to the excess risk of CVD. Keeping in view the prevalence and increased risk of cardiovascular disease in diabetes, it is becoming necessary to diagnose prediabetic individuals and assess their lipid profile and prevent them from developing overt diabetes ...

BACKGROUND Recent evidence has suggested an association between subclinical hypothyroidism (SCH) and microalbuminuria in patients with type 2 diabetes. However, whether SCH is related to microalbuminuria among subjects with prediabetes has not been studied. Thus, we evaluated the association between SCH and microalbuminuria in a cohort of prediabetic Egyptian adults. METHODS A total of 147 pr...

Background: Diabetes mellitus, a group of metabolic disorder with multiple etiologies is characterized by chronic hyperglycaemia, induced deficiency insulin production and action. Prediabetes type hyperglycemia in which glycemic indices are higher than normal but lower the diabetes threshold. Objective: This study aims to assess impact bone markers (serum calcium, phosphorus alkaline phosphatas...

OBJECTIVE To determine if prediabetes is associated with atherosclerosis of coronary arteries, we evaluated the degree of coronary atherosclerosis in nondiabetic, prediabetic, and diabetic patients by using coronary angioscopy to identify plaque vulnerability based on yellow color intensity. RESEARCH DESIGN AND METHODS Sixty-seven patients with coronary artery disease (CAD) underwent angiosco...

background & objectives: alloxan & streptozotocin are used for inducing diabetic models. their combination has been used to reduce the individual chemical dosage and minimize the side effects. present investigation was aimed at studying pre-diabetic clinical changes induced by low doses of alloxan-stz cocktail in rabbits. methods: new zealand white rabbits, 1-1.5 kg body weight, were a...