نتایج جستجو برای: praziquantel

تعداد نتایج: 1687  

2014
Jennifer Keiser Kigbafori D. Silué Lukas K. Adiossan Nicaise A. N'Guessan N'Chou Monsan Jürg Utzinger Eliézer K. N'Goran

BACKGROUND Treatment and morbidity control of schistosomiasis relies on a single drug, praziquantel. Hence, there is a pressing need to develop additional therapeutics against schistosomiasis. The antimalarial drug mefloquine shows antischistosomal activity in animal models and clinical trials, which calls for further investigations. METHODOLOGY We comparatively assessed the efficacy and tole...

Journal: :The Journal of antimicrobial chemotherapy 2011
Jennifer Keiser Theresia Manneck Mireille Vargas

OBJECTIVES Mefloquine has interesting antischistosomal properties, hence it might be an attractive partner drug for combination treatment with praziquantel. The aim of this study was to evaluate activities of mefloquine/praziquantel combinations against Schistosoma mansoni in vitro and in vivo. METHODS Dose-response relationships were established following exposure of adult S. mansoni to mefl...

2011
Sun Young Kyung Yong Kyun Cho Yu Jin Kim Jeong-Woong Park Sung Hwan Jeong Jae-Ik Lee Yon Mi Sung Sang Pyo Lee

Paragonimiasis is an infectious disease caused by trematodes of the genus Paragonimus. This trematode can be treated successfully with praziquantel in more than 90% of the cases. Although praziquantel is generally well tolerated, anaphylactic reactions to this drug have been reported in a few cases. We report here a 46-year-old Korean female with paragonimiasis, presumed to be due to Paragonimu...

Journal: :Diseases of aquatic organisms 2000
K H Kim J B Cho

The antiparasitic efficacy of praziquantel against the blood-sucking polyopisthocotylean Microcotyle sebastis was tested in an experimental cage simulating commercial rockfish-culture conditions. Juvenile rockfish Sebastes schlegeli were separated into 4 pilot net-pens, and the fish in the groups were either fed a control diet (Group C), fed a praziquantel-adsorbed diet (Group F), bathed in 100...

Journal: :The Journal of infectious diseases 1997
F F Stelma S Sall B Daff S Sow M Niang B Gryseels

An outbreak of Schistosoma mansoni in northern Senegal was observed in 1988, and chemotherapy with praziquantel in this recently established focus resulted in very low parasitologic cure rates. Among other explanations, the emergence of a praziquantel-tolerant parasite strain was feared. To study this hypothesis further, 138 persons with endemic S. mansoni infection were randomly allocated to t...

Journal: :Journal of Antimicrobial Chemotherapy 1985

2013
Martial L. Ndeffo Mbah Eric M. Poolman Katherine E. Atkins Evan W. Orenstein Lauren Ancel Meyers Jeffrey P. Townsend Alison P. Galvani

BACKGROUND Epidemiological data from Zimbabwe suggests that genital infection with Schistosoma haematobium may increase the risk of HIV infection in young women. Therefore, the treatment of Schistosoma haematobium with praziquantel could be a potential strategy for reducing HIV infection. Here we assess the potential cost-effectiveness of praziquantel as a novel intervention strategy against HI...

Journal: :Acta tropica 2001
J Utzinger J Chollet J You J Mei M Tanner S Xiao

Praziquantel and artemether are safe and efficacious antischistosomal drugs that act against different developmental stages of the parasite: praziquantel against adult worms and artemether against schistosomula. A combined treatment has been suggested as a strategy for transmission control. Recent laboratory experiments with rabbits with a mixed infection of Schistosoma japonicum parasites of d...

2013
Jong-Yil Chai

Status and emerging issues in the use of praziquantel for treatment of human trematode and cestode infections are briefly reviewed. Since praziquantel was first introduced as a broadspectrum anthelmintic in 1975, innumerable articles describing its successful use in the treatment of the majority of human-infecting trematodes and cestodes have been published. The target trematode and cestode dis...

Journal: :archives of clinical infectious diseases 0
abdollah rafiei infectious diseases and tropical medicine research center, jundishapur university of medical sciences, ahwaz, ir iran; infectious diseases and tropical medicine research center, jundishapur university of medical sciences, ahwaz, ir iran mohammad hassan pipelzadeh department of pharmacology, jundishapur university of medical sciences, ahwaz, ir iran abdolhadi jahanshahi department of surgery, jundishapur university of medical sciences, ahwaz, ir iran mohammad reza erfanian salim department of surgery, jundishapur university of medical sciences, ahwaz, ir iran

background due to danger of spillage of cyst materials during surgery, chemoprophylaxis is routinely recommended for cyctic echinococcosis. however, for prophylactic purposes the time for starting and the duration of administration of prophylactic drug regimen is not yet clear. the aim of the present study was to evaluate the chemoprophylactic efficacy of one month administration of albendazole...

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