Cough affects all individuals at different times, and its economic burden is substantial. Despite these widespread adverse effects, cough research relies on animal models, which hampers our understanding of the fundamental cause of cough. Postnasal drip is speculated to be one of the most frequent causes of chronic cough; however, this is a matter of debate. Here we show that mechanical stimuli...

There are increasing evidences that allergic rhinitis (AR) may influence the clinical course of asthma. We conducted methacholine challenge test and nasal eosinophils on nasal smear to patients with allergic rhinitis in order to investigate the mechanism of connecting upper and lower airway inflammation in 35 patients with AR during exacerbation. The methacholine concentration causing a 20% fal...

BACKGROUND Anticholinergic agents, specifically the quaternary salt of atropine, are currently being recommended for chronic rhinitis and the common cold. OBJECTIVE To evaluate the efficacy and safety of 50- and 75-microg doses of atropine sulfate as a nasal spray in perennial allergic rhinitis. METHODS A placebo-controlled, double-blind study compared 2 doses of atropine nasal spray given ...

evidence acquisition in this study, we examined a major resource of itm, the qanoon fi al-teb (the canon of medicine), by avicenna and the writings of prominent ancient scholars and physicians on the origins of catarrh. pubmed and google scholar were also searched for information on pnd and catarrh, and they were compared with the catarrh in itm. results physicians of itm believe that the main ...

BACKGROUND The occurrence of nasopharyngeal tuberculosis is rare even in areas where tuberculosis is endemic. Here, we report a case of rare primary nasopharyngeal tuberculosis, promptly evaluated by nasolaryngoscopy. CASE PRESENTATION A 78-year-old woman presented with postnasal drip and a cough of 1-month duration. Endoscopic examination of the nasopharynx revealed irregular mucosal thicken...

might resolve over time is not an optimal approach. We recommend that a first-generation antihistamine-decongestant (our choice is sustained release brompheniramine, 12 mg, and pseudoephedrine, 120 mg every 12 h) be administered as the initial therapy whatever the duration of cough, unless there is a contraindication to one of these drugs. This empiric approach makes sense because postnasal dri...