introduction and aims: tt virus (ttv) is a dna virus and is proposed as a potential cause of non-a to e hepatitis. we aimed to investigate, for the first time, the prevalence of ttv in iranian healthy blood donors. materials and methods: three hundred and twelve healthy iranian blood donors were randomly selected and tested for ttv dna by the seminested polymerase chain reaction method. serum a...

Canada has not introduced the non-A, non-B (NANB) surrogate marker tests (antibodies to hepatitis B core antigen and alanine aminotransferase) to screen donated blood. We evaluated the effect of NANB surrogate markers in reducing post-transfusion hepatitis in a prospective randomised intervention study. From 1988 to 1992, 4588 subjects were enrolled into two study groups that received allogenei...

Hepatitis C virus is the main agent responsible for post-transfusion hepatitis. Progression to chronic hepatitis, cirrhosis and hepatocellular carcinoma is very common. The aim of this study was to evaluate the frequency, timing and factors related to progression of hepatitis C. One hundred seventy five patients with chronic post-transfusion hepatitis C were grouped in a cirrhosis group (n = 92...

In 144 cases of hepatocellular carcinoma (HCC), 166 cases of cirrhosis without HCC and 142 cases of chronic hepatitis, we examined HBsAg, anti-HBs and anti-HBc in sera and compared the following factors between hepatitis B virus marker-negative and -positive patients: age, sex, alcohol consumption, family clustering of liver diseases, and histories of blood transfusion and post-transfusion hepa...

To evaluate the incidence of post-transfusion hepatitis and factors influencing its occurrence, the Transfusion-Transmitted Viruses Study prospectively followed 1513 transfusion recipients from 1974 through 1979. The attack rate for non-A,non-B hepatitis was 10 per cent. The incidence of hepatitis was directly related to the alanine aminotransferase (ALT) level in blood donors. In recipients of...

To study the frequency of post-transfusion non-A, non-B (NANB) hepatitis in Finland, we have followed prospectively 65 patients after open-heart surgery. The total number of transfused blood units was 652. Blood samples were obtained from the patients during the first 6 months after the operation and were studied for transaminase levels. The NANB diagnosis was based on exclusion of viral hepati...