Objective(s): Cirrhotic cardiomyopathy is a complication of uncured cirrhosis which is associated with hyporesponsiveness of the heart to sympathetic stimulation. The enhancement of portal pressure, nitric oxide (NO) level, pro-inflammatory mediators and down-regulation of Suppressor of Cytokine Signaling 1 (SOCS1) are involved in this situations. The present study see...

conclusions apbsc transplantation greatly benefits hbv-linked decompensated cirrhosis patients and should be recommended in clinical practice. patients and methods this prospective study included 68 hospitalized patients who were diagnosed with hbv-related decompensated cirrhosis. these patients were divided into two groups: the transplantation group included 33 patients, while the control grou...

We report a case of a 40 year old man with portal hypertension caused by a splenic arteriovenous fistula that was diagnosed at laparotomy. He presented with bleeding esophageal varices and was initially treated by sclerotherapy. At laparotomy, portal pressure was 40 cmH20 but fell to 20 cm H20 after the fistula was treated with splenectomy. All symptoms disappeared shortly after operation ...

Portal pressure-blood volume curves were derived in 13 cirrhotic patients with portal hypertension and oesophageal or gastric varices by measuring portal pressure at two levels of blood volume. Portal pressure varied directly with blood volume. In seven patients where portal pressure was measured at three levels of blood volume separated by 500 ml or more the portal pressure-blood volume relati...

To determine the relationship of splanchnic blood flow and portal venous resistance to elevated portal pressure, in situ perfusion of the splanchnic circuit was carried out in 12 freshly killed dogs at varying perfusion rates and degrees of acute and chronic portal vein constriction. In six normal dogs before being killed, portal pressure averaged 8-8 +/- 1-2 mmHg and portal flow 658 +/- 81 ml/...

1. In the liver of portal cirrhosis there is a far freer communication between the arterial and portal currents than in the normal liver. 2. Factors contributing to the increased portal pressure in portal cirrhosis are (1) the direct communication of the arterial pressure to the portal vessels through dilated capillaries, (2) the larger volume-flow of the hepatic artery in proportion to the por...

Twenty-eight patients with hepatosplenic schistosomiasis and portal hypertension were studied. The transumbilical portal pressure, transsplenic portal pressure, and thoracic duct occluded pressure were measured simultaneously and thoracic duct lymph flow estimated. Changes in the splanchnic vasculature were studied radiologically barium swallow, splenoportography, and umbilical portography. The...

Endothelin is a vasoconstrictor peptide which has recently been isolated and sequenced from the vascular endothelial cells. It was reported to increase blood pressure in vivo and produce a prolonged contraction with a slow onset in vitro. The purpose of this study was to investigate whether endothelin can lower the portal pressure as another endogenous vasoconstriction peptidevasopressin (AVP) ...

Portal hypertension is a clinical syndrome defined by a pathological increase in portal pressure. The development of cirrhosis of the liver is characterized by clinical manifestations related to portal hypertension like esophageal varices, ascites, bleeding, and encephalopathy. Direct measurement of portal pressure is invasive, inconvenient, and clinically impractical. Currently, the most commo...