failure to respond adequately to standard protocols and to recruit adequate follicles is called ‘poor response’. this results in decreased oocyte production, cycle cancellation and, overall, is associated with a significantly diminished probability of pregnancy. it has been shown that ovarian reserve tests, such as basal fsh, antimullarian hormone (amh), inhibin b, basal estradiol, antral folli...

background: poor ovarian response phenomenon has been observed in some of the in vitro fertilization-embryo transfer patients. some investigations found that follicle stimulating hormone receptor (fshr) gene plays a role in the process, but no direct evidence shows the correlation between genotypes of fshr and ovarian response. objective: exploring the molecular mechanism behind the mutation of...

background: poor ovarian response to controlled ovarian stimulation is one of the most important interest points in assisted reproduction. mild ovarian stimulation seems to be preferable to high dose of fsh regimens in women with a history of poor ovarian response in previous protocol. clomiphene citrate and letrozole alone or in combination with fsh have been used in mild ovarian stimulation p...

background: the ability of the ovary to respond to exogenous gonadotrophin stimulation and development of several follicles is essential in assisted reproductive technology. neither age and regularity of menses nor follicular phase fsh and estradiol concentrations are reliable predictors of ovarian response. day 3 serum inhibin-b level, during induction ovulation, has been proposed as a predict...

The management of poor responders in IVF cycles is extremely controversial due to their inadequate response to controlled ovarian hyperstimulation.. A low ovarian response may be idiopathic or may be associated with many different factors including age, diminished ovarian reserve, endometriosis and prior ovarian surgery, and a reported incidence 9-24% of IVF patients. Several strategies have be...

background: despite extensive progress in ivf techniques, one of the most difficult problems is the variability in the response to controlled ovarian hyperstimulation (coh). recent studies show the effects of individual genetic variability on coh outcome. objective: to evaluate the correlation between lhβ g1502a polymorphisms in exon 3 of the lh gene and ovarian response to coh. materials and m...

Background: One of the most annoying problems in IVF is poor ovarian response. It is anticipated that 5-18% of all IVF cycle are affected by poor response to ovarian hyperstimulation. Poor response to goandotropin may lead to decline in the pool of embryos for transfer or cryoperservation, and decrease pregnancy rates. Different mechanisms explain poor ovarian response for example decreased num...

background: reduced ovarian reserve has been known to predict poor ovarian response and poor success rates in infertile women undergoing assisted reproductive technology. ovarian reserve also decreases with age but the rate of decline defers from a woman to another. the aim of this study was to detect any difference in ovarian reserve as measured by basal serum fsh and amh between matched cohor...

BACKGROUND The most common genetic variant of luteinizing hormone (LH), variant-betaLH, has a different bioactivity than the wildtype. Carrying the variant allele was associated with an increased consumption of exogenous gonadotropin to achieve optimal ovarian response for in vitro fertilization procedures (IVF). The aim of this study was to examine if variant-betaLH was also more common in pat...