abstract a simple and sensitive chemiluminescence (cl) method was developed for direct quantification of oxymorphone, a µ opioid agonist that is approximately 10 times more potent than morphine. in this method potassium permanganate in polyphosphoric acid was used as cl reagent. using this method, oxymorphone can be determined over the concentration ranges 13.5-337.8 ng ml-1 and 0.34-6.76 µg ml...

3-Carbamoylmethyl-Indole-1-Carboxylic Acid Ethyl Ester (an ethoxycarbonyl derivative of indole-3-acetamide) is obtained by Friedel–Crafts type cyclocondensation γ-functionalized acetoacetamide in neat polyphosphoric acid.

In studies of the enzymatic oxidation of 6-phosphogluconate, relatively large quantities of this substance in high purity were required. This led to a search for a convenient preparation of glucoseB-phosphate. Available methods for the synthesis of glucose-6-phosphate, reviewed by Lardy et al. (1, 2), are laborious and not well suited to the preparation of large quantities of this substance. A ...

This study explores the effects of polyphosphoric acid (PPA) on rheological performance styrene butadiene (SBS) and crumb rubber (CR) modified asphalt binders at high temperatures. Four PPA concentrations were selected: 0.4%, 0.8%, 1.2%, 1.6% by weight virgin asphalt, one SBS binder with 5% was used as a reference binder. Laboratory tests performed to simulate short-term long-term aging. Temper...

the facile and high yield synthesis of a new series of dibenzophenones in the presence of polyphosphoric acid (ppa) together with their cyclization to corresponding moni and dixanthones are described. the aromatic nucleophilic substitution of these new compounds are also studied.

3-Substituted 2-quinolones are obtained via a novel, metal-free transannulation reaction of 2-substituted indoles with 2-nitroalkenes in polyphosphoric acid. The reaction can be used in conjunction with the Fisher indole synthesis offering a practical three-component heteroannulation methodology to produce 2-quinolones from arylhydrazines, 2-nitroalkenes and acetophenone.

Abstract Here we report an efficient and short total synthesis of bulgarein ( 1 ), a natural compound from Bulgaria inquinans with cytotoxic activity. Key steps in the are Suzuki‐Miyaura coupling reaction two substituted naphthalene derivates followed by polyphosphoric acid (PPA) mediated condensation to form benzo[ j ]fluoranthene skeleton. Bulgarein ) was achieved over 4 overall yield 25 %.

The cyclization of b-anilino propionic acids in the presence of polyphosphoric acid (PPA) afforded the 2,3-Dihydroquinoline-4-(1H)-ones in good yields. N,N'-bis(2-carboxyethyl)-4-methyl-1,2-diaminobenzene (7) is cyclized under this condition to produce the 1,5-diaza-2,3,6,7-tetrahydro-4-methyl-pheranthrene-4,8-dione(bis-quinolone) (8).