thermodynamic features related to preparation and use of self-assemblies formed between multilamellar and unilamellar zwitterionic liposomes and polynucleotides with various conformation and sizes are presented. the divalent metal cation or surfactant-induced adsorption, aggregation and adhesion between single- and double-stranded polyribonucleotides and phosphatidylcholine vesicles was followe...

Chemical analysis of metalized DNA has made it quite clear that traditional models thermodynamics are insufficient to predict and control self-assembly in the context orthogonally-paired nucleotides. Recently, there been an increase reports Watson-Crick assembly wires nanostructures [1–4]. The ability add or remove pairing rules between nucleobases toward non-Watson-Crick, orthogonal, alters fu...

OBJECTIVE A theory of fuzzy polynucleotides, including an n-dimensional metric fuzzy polynucleotide space, has been previously introduced by the present author for fuzzy-theoretical analysis of nucleic acids [Sadegh-Zadeh K. Fuzzy genomes. Artif Intell Med 2000;18:1-28; Sadegh-Zadeh K. Ein Verfahren zur Fuzzydecodierung und Fuzzydechiffrierung von Informationen. Offenlegungsschrift DE 199 36 92...

There is a very close steric relationship between the codon-anticodon site which accounts for the genetic code dictionary and a polynucleotide replicase site. Protein biosynthesis must therefore have arisen out of a primaeval polynucleotide replicase system.

Water soluble homo-base polynucleotide analogues were synthesized in which polyvinyl alcohol and partially phosphonated polyvinyl alcohol constituted the backbones,onto which were grafted uracil or adenine via 1,3-dioxane spacers formed by acetal formation with the 1,3-diol moieties in PVA. The resulting adenine-PVA polynucleotide analogs exhibited hyperchromic effects, which was not the case f...

this review reports recent advances in metallic nanostructures based electrochemical sensors. interesting aspects of nps include size and shape-dependent interatomic bond distances, melting points, chemical reactivity, and optical and electronic properties. the small size of metallic nanostructures has allowed nanoscale electrochemical processes to be probed. electrochemical characteristics can...

The possible backbone phosphodiester conformations in a dinucleoside monophosphate and a dinucleoside triphosphate have been investigated by semiempirical energy calculations. Conformational energies have been computed as a function of the rotations omega' and omega about the internucleotide P-O(3') and P-O(5') linkages, with the nucleotide residues themselves assumed to be in one of the prefer...