BACKGROUND The purpose of this study was to test the efficacy of cyclic Arg-Gly-Asp (RGD) peptide conjugated with polyionic complex nanomicelles as targeted therapy for glioma. METHODS A stable cyclic RGD polyionic complex nanostructure, ie, a c(RGDfC) polyionic complex micelle, was synthesized and its biocompatibility with cultured neurons was assessed using a cell viability assay. Targeted ...

In response to advances in proteomics research and the use of proteins in medical and biotechnological applications, recombinant protein production and the design of specific protein characteristics and functions has become a widely used technology. In this context, protein fusion tags have been developed as indispensable tools for protein expression, purification, and the design of functionali...

The preparation of monolithic polyionic supports which serve as efficient heterogeneous supports for palladium(0) nanoparticles is described. These functionalized polymers were incorporated inside a flow reactor and employed in Suzuki-Miyaura and Heck cross couplings under continuous flow conditions.

Mucus is an ubiquitous polymer hydrogel that functions as a protective coat on the surface of integument and mucosa of species ranging from simple animals (such as coelenterates) to mammals. The polymer matrix of mucus is made out of long-chain glycoproteins called mucins that are tangled together, forming a randomly woven, highly polyionic network (Lee et al., 1977; Verdugo et al., 1983). Muci...

In the current issue of ACS Nano, Löbling, Haataja et al. craft polymeric nanoparticles with a hierarchy of nontrivial surface structures by combining conventional interpolyelectrolyte complexation with steric control from an uncharged copolymer block. Remarkable cylindrical and lamellar nanodomains are produced on the polyionic coronae of spherical micelles. Here, we discuss generalizing this ...

VI. REACTION MoMErcr AND ELECTRIc-CI~-.MICAL MECHANISM 1. Reaction Moments from Dielectric Data 2. Permanent and Induced Dipole Moments (a) Individual dipole moments (b) Total polarization (i) Induced moment (ii) Permanent moment (c) Form factors and g-factors 3. Reaction Moment and Equilibrium Constant (a) Non-polar polarizable spheres (b) Polar non-polarizable spheres (c) Polar polarizable sp...