INTRODUCTION To reduce the risk of local infections after surgical treatments for HPV infected cervical lesions, the post-operative regimen is generally based on the use of vaginal antimicrobial agents. AIM The efficacy and safety of polyhexamethylene biguanide-based vaginal suppositories was compared to a similar chlorhexidine-based treatment, in the post recovery regimen after surgical trea...

BACKGROUND Pin site infection is a common problem in external fixation. Plain gauze wetted with normal saline is commonly used for a pin site dressing owing to the simplicity and low cost. Evidence to support adding an antimicrobial agent in the dressing material is lacking. QUESTIONS/PURPOSES We compared the rate of pin tract infection using plain gauze and gauze impregnated with polyhexamet...

BACKGROUND Use of oral antiseptics decreases the bacterial load in the oral cavity. OBJECTIVE To compare the antimicrobial activity of 3 novel oral antiseptics with that of chlorhexidine, which is considered the "gold standard" of oral hygiene. DESIGN Comparative in vitro study. METHODS Four common oral microorganisms (Streptococcus sanguinis, Streptococcus mutans, Candida albicans, and F...

purpose: to assess the efficacy of polyhexamethylene biguanide (phmb) in treating acanthamoeba keratitis (ak) and also to identify related factors affecting final visual outcome in ak patients treated with phmb methods: in these interventional case series study, 27 eyes of 25 patients with ak received phmb 0.02% and divided into two groups according to the final visual acuity (va) va equal to o...

PURPOSE To assess dose- and concentration-dependent rates of biguanides on the viability of Acanthamoeba cysts isolated from severe ulcerative keratitis, and to correlate cysticidal activites with cytotoxic profiles in corneal and endothelial cells. METHODS Cysticidal activities of polyhexamethylene biguanide and chlorhexidine digluconate were evaluated in the Acanthamoeba castellanii strain ...

Interviews with the patient that were conducted after the wound had healed were used in order to reflect on his hospital journey and gain insights into his treatment experience. This article demonstrates that new wound product innovations such as Suprasorb X+PHMB (polyhexamethylene biguanide) (Activa Healthcare), along with a multidisciplinary approach, can result in positive outcomes in comple...

REVIEW QUESTION/OBJECTIVE The objective of this review is to review and synthesize evidence on the effectiveness of polyhexamethylene biguanide (PHMB) impregnated dressing in wound treatment for patients with chronic or acute wounds, compared with standard dressings or any other antimicrobial dressings.Specifically the questions for this review are.