Les polyendocrinopathies auto-immunes (PEAI) designent lapparition de deux ou plusieurs atteintes endocrines auto-immunes, associees non a dautres maladies endocrines. Le diabete type 1 saccompagne dune frequence elevee auto-immunes. Lobjectif notre travail est determiner les differents aspects epidemiologiques, cliniques, immunologiques, therapeutiques des autoimmunes au cours du et danalyser ...

Despite declining infant-mortality rates and a cottage industry of publications devoted to improving parenting/childcare, birthrates in the U.S. and Western Europe continue to fall. But the present inquiry is directed less to the disappearance of actual children than to that more fragile and contested state of childhood. Changes in the spaces reserved for childhood might be compared to the eros...

autoimmune polyglandular syndrome (aps) type 2 is characterized by the presence of addison's disease, in association with autoimmune thyroid disease and/or type 1 diabetes mellitus. aps type 2 occurs most often in middle aged females and is rare in children. here an 11 year old boy is reported with addison's disease who developed symptom's of diabetes mellitus, goiter, malabsorption, macrocytic...

Brindley, D. N. & Bowley, M. (1975) Biochem. J. 148,461-469 Fallon,H. J.,Banvick, J.,Lamb,R.G. &vandenBosch,H.(1975)J. LipidRes. 16,107-115 Lamb, R. G. & Fallon, H. J. (1974~) Biochim. Biophys. Actu 348, 166178 Lamb, R. G. & Fallon, H. J. (19746) Biochim. Biophys. Actu 348, 179-188 Lamb. R. G.. Wood, C. K., Guzelian, P. S. & Fallon, H. J. (1976) Fed. Proc. Fed. Am. SOC. Exp. Biol. 35,746 Lamb, ...

Methods 1124 visits in 255 JIA patients were evaluated. Correlations of JADAS-27 (range 0-57) with JADAS-10, JADAS-71, core-set criteria, Disease Activity Index (DAS-28), and Clinical Disease Activity Index (CDAI) were analyzed in the total group and treatment groups. Responsiveness to minimal clinically important difference (MCID) was analyzed longitudinally. Worsening was defined as a flare w...

Genetic alterations are known drivers of autoimmune disease; however, there is a much higher incidence of autoimmunity in women, implicating sex-specific factors in disease development. The autoimmune regulator (AIRE) gene contributes to the maintenance of central tolerance, and complete loss of AIRE function results in the development of autoimmune polyendocrinopathy syndrome type 1. In this i...

Introduction The antiphospholipid antibody syndrome (APS) is a multisystemic autoimmune disease characterized by thromboembolic events, pregnancy morbidity, hematologic, dermatologic, neurologic and other manifestations in the presence of elevated titers of antiphospholipid antibodies (aPL). In recent years, APS has been increasingly recognized in various pediatric autoimmune and nonautoimmune ...