Neutron reflectivity measurements were performed on a cell membrane mimic system consisting of a polyelectrolyte multilayer plus a synthetic terpolymer plus a phospholipid layer, at all of the intermediate steps in the assembly of the composite, to obtain neutron scattering length density depth profiles. The polyelectrolyte multilayer functions as a soft, water-containing cushion for the membra...

thermodynamic features related to preparation and use of self-assemblies formed between multilamellar and unilamellar zwitterionic liposomes and polynucleotides with various conformation and sizes are presented. the divalent metal cation or surfactant-induced adsorption, aggregation and adhesion between single- and double-stranded polyribonucleotides and phosphatidylcholine vesicles was followe...

The anionic conjugated polyelectrolyte, poly[3-(6-sulfothioatehexyl)thiophene] (P3Anionic), functions as a highly sensitive probe of membrane order, uniquely capable of sequentially detecting the three key phase transitions occurring within model phospholipid bilayers. The observed sensitivity is the result of charge-mediated, selective localisation of P3Anionic within the head-groups of the ph...

Lipid bilayer membranes supported on polyelectrolyte multilayers are widely used as a new biomembrane model that connects biological and artificial materials since these ultrathin polyelectrolyte supports may mimic the role of the extracellular matrix and cell skeleton in living systems. Polyelectrolyte multilayers were fabricated by a layer-by-layer self-assembly technique. A quartz crystal mi...

Membrane-spanning phospholipid bolaamphiphiles either alone or as a constituent of a multicomponent lipid membrane may prove to be facile building blocks for generating robust bioactive membrane-mimetic assemblies. We have previously reported the synthesis of asymmetric dialkyl phospholipid bolaamphiphiles that contain ester linked phosphatidylcholine and amine functionalities at opposite chain...

Gold nanorods (AuNRs) have attracted a great deal of attention due to their potential for use in wide range biomedical applications. However, production typically requires the relatively toxic cationic surfactant cetyltrimethylammonium bromide (CTAB) leading continued demand protocols detoxify them vivo In this study, robust and facile protocol displacement CTAB from surface AuNRs using phospho...

Addition of a weak polyelectrolyte, poly(methacrylic acid) (PMA), to a supported phospholipid bilayer made from 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) depresses the melting temperature and alters the morphology of the bilayer in the gel phase. Ellipsometry measurements show that PMA adsorption lowers the phase transition temperature by 2.4 degrees C. Atomic force microscopy (AFM) sh...

the paper is focused on the formation of hydroxyapatite nanoparticles (hap) in polyelectrolyte-modified microemulsions, in a microemulsion template phase consisting of cyclohexane, water, cationic surfactant and cosurfactant, in the presence of na-polyacrylate (paa) as an anionic polyelectrolyte. it is shown that paa, can be incorporated into the individual inverse microemulsion droplets. the m...

the paper is focused on the formation of calcium phosphate nanoparticles (cp) in polyelectrolyte-modified microemulsions, in a microemulsion template phase consisting of cyclohexane, water, anionic surfactantant and cosurfactant, in the presence of anionic and cationic polyelectrolyte. it is shown that polyelectrolyte, can be incorporated into the individual inverse microemulsion droplets. the ...

The paper is focused on the formation of calcium phosphate nanoparticles (CP) in polyelectrolyte-modified microemulsions, in a microemulsion template phase consisting of cyclohexane, water, anionic surfactantant and cosurfactant, in the presence of anionic and cationic polyelectrolyte. It is shown that polyelectrolyte, can be incorporated into the individual inverse microemulsion droplets. The ...