primary sjorgen syndrome is one of the commonest autoimmune diseases with characteristic of involvement of lachrymal and salivary glands, but other organ involvements as peripheral and central nervous system are also possible. the reported case is a 23 year old lady presented with progressive sensory ataxia and weakness of four limbs, bilateral sensory hearing loss and cognitive impairment with...

Background: With the growing number and variety of chemical agents used in industry for home purposes, burns their consequences have drawn physicians’ attention. Involvement nervous system that is a major consequence systemic exposure can be problematic local burns, as well. This study was designed to evaluate peripheral burn victims. Objectives: Investigating neuropathy prevalence patients wit...

Poly(ADP-ribose) polymerase (PARP) activation is emerging as a fundamental mechanism in the pathogenesis of diabetes complications including diabetic neuropathy. This study evaluated the role of PARP in diabetic sensory neuropathy. The experiments were performed in control and streptozotocin-induced diabetic rats treated with or without the PARP inhibitor 1,5-isoquinolinediol (ISO; 3 mg x kg(-1...

Diabetic poly neuropathy (DPN) is the most common chronic complication of type 2 diabetes. Aim of this observational cross sectional study is to establish correlation between level of TNF α and severity of DPN if any. The forty seven subjects were divided into three groups. Group1:15 healthy normal controls; Group2:12 T2DM patients without neuropathy controls; Group3:20 T2DM patients with painf...

Type 2 Diabetes mellitus is a disease which manifests with a variety of cardiovascular risk factors, including hypertension, dyslipidemia and overweight or obesity that contributes to development of long term complications termed diabetic related ailments. Diabetic peripheral neuropathy (DPN) is a debilitating condition affecting as many as one half of all patients with diabetes during the cour...

Oxidative and nitrosative stress play a key role in the pathogenesis of diabetic neuropathy, but the mechanisms remain unidentified. Here we provide evidence that poly(ADP-ribose) polymerase (PARP) activation, a downstream effector of oxidant-induced DNA damage, is an obligatory step in functional and metabolic changes in the diabetic nerve. PARP-deficient (PARP(-/-)) mice were protected from b...