in this study, microspheres containing estradiol valerate were prepared by solvent evaporation method using poly (glycolide-co-lactide) (plga 50:50) and poly (lactide). the effect of different process variables such as polymer type, drugpolymer ratio, stirring rate, volume of internal phase and temperature of external phase on the morphology, particle size distribution, encapsulation efficiency...

the effects of magnesium hydroxide and l-lactide dimer as additives on thermal properties and morphology of poly(l-lactide) (plla) films were studied. hence, neat plla films and films containing additives (10% w/w) were prepared in dichloromethane at room temperature via solution casting. to evaluate thermal history on polymer properties, plla films were annealed by different processes. in one ...

in this work, new biodegradable abcba type pentablock copolymers with different mole ratio of l-lactide and ppdo-b-peg-b-ppdo triblock copolymer were synthesized and characterized. in the first step, ppdo-b-peg-b-ppdo triblock copolymer was synthesized via a ring-opening polymerization of p-dioxanone (pdo) monomer with poly (ethylene glycol) (peg) using stannous octoate (sn(oct)2) as the cataly...

In this work, new biodegradable ABCBA type pentablock copolymers with different mole ratio of L-lactide and PPDO-b-PEG-b-PPDO triblock copolymer were synthesized and characterized. In the first step, PPDO-b-PEG-b-PPDO triblock copolymer was synthesized via a ring-opening polymerization of P-DiOxanone (PDO) monomer with Poly (Ethylene Glycol) (P...

lactide was synthesized by reverse polymerization of low molecular weight poly(lactic acid) with two different molecular weights:1500 and 2500. two different lactide purification processes such as: recrystallization in ethyl acetate and washing the crude lactide with ether before recrystallization in ethyl acetate were evaluated. it has been demonstrated that increasing the molecular weight of ...

The helium and oxygen gas barrier properties of poly(lactide) were investigated as a function of stereochemistry and crystallinity degree. Poly(L-lactide) and poly(D,L-lactide) films were obtained by extrusion and thermally cold crystallized in either a0or a-crystalline form with increasing crystallinity degree. Annealing of the films at low temperatures yielded to a0-crystals as well as the cr...

The simultaneous improvement of the melting temperature (T(m) = 224 °C) and the decomposition temperature (T(10) = 359 °C) of poly(lactide)s was achieved by the stereocomplex formation of poly(l-lactide) and poly(d-lactide) with bio-based aromatic groups at both initiating and terminating chain ends.

Poly (DL-lactide)/Poly (ethylene glycol) diblock copolymer is successfully synthesized with mPEG and DL-LA as main raw materials, the residual monomers of polymer were removed by recrystallization. FT-IR used to characterize structure polymer. Gas chromatography determine solvent The solubility in different solvents was determined, effect systems on removal discussed. results showed that Poly(D...

This article reports experimental data related to the research article entitled "Poly(malic acid-co-l-lactide) as a Superb Degradation Accelerator for Poly(l-lactic acid) at Physiological Conditions" (H.T. Oyama, D. Tanishima, S. Maekawa, 2016) [1]. Hydrolytic degradation of poly(l-lactic acid) (PLLA) blends with poly(aspartic acid-co-l-lactide) (PAL) and poly(malic acid-co-l-lactide) (PML) oli...

Novel biodegradable and pH-sensitive polymersomes prepared from poly(ethylene glycol) and poly(d,l-lactide) grafted poly(beta-amino ester) exhibit pH dependent permeability on hydrophilic solutes of which permeability is determined by the packing state of poly(d,l-lactide) membrane followed by ionization of poly(beta-amino ester) inducing loosely packed membrane formation from well-ordered pack...