peripheral nerve injuries caused by traffic accidents, resections of tumors or iatrogenic side effects of the surgeries are few of the most common form of trauma occurring with up to 500,000 cases each year in iran. conventional strategies including nerve coaptation, and the application of autografts, allografts and xenografts are restricted due to the limited availability of donors, immune-rej...

Poly(L-lactic acid) is a linear aliphatic thermoplastic polyester that can be produced from renewable resources. A poly(L-lactic acid)-modified silica stationary phase was newly prepared by amide bond reaction between amino groups on aminopropyl silica and carboxylic acid groups at the end of the poly(L-lactic acid) chain. The poly(L-lactic acid)-silica column was characterized in reversed-phas...

physical, mechanical and structural properties of poly(lactic acid) (pla)-basedfilms containing different amounts of nanoclay and cellulose prepared bysolvent casting method were examined. physical properties including thickness,transparency and color did not change significantly with addition of nanoparticles to the polymer matrix. x-ray diffraction (xrd) patterns showed that pure pla has a se...

Tensile stress and tensile strain directly affect the quality of nerve regeneration after bridging nerve defects by poly(lactic-co-glycolic acid) conduit transplantation and autogenous nerve grafting for sciatic nerve injury. This study collected the sciatic nerve from the gluteus maximus muscle from fresh human cadaver, and established 10-mm-long sciatic nerve injury models by removing the isc...

OBJECTIVE The aim of this study was to investigate bone repair after the implantation of vancomycin-loaded poly-L-lactic acid/poly-ethylene oxide microspheres compared with vancomycin-unloaded poly-L-lactic acid/poly-ethylene oxide microspheres. METHODS Poly-L-lactic acid/poly-ethylene oxide microspheres were implanted in rat tibiae and evaluated for periods of 2, 4, 8, and 12 days and 4, 8, ...

lactide was synthesized by reverse polymerization of low molecular weight poly(lactic acid) with two different molecular weights:1500 and 2500. two different lactide purification processes such as: recrystallization in ethyl acetate and washing the crude lactide with ether before recrystallization in ethyl acetate were evaluated. it has been demonstrated that increasing the molecular weight of ...

background: disulfiram is oral aldehyde dehydrogenase (aldh) inhibitor that has been used in the treatment of alcoholism. recent studies show that this drug has anticancer properties; however, its rapid degradation has limited its clinical application. encapsulation of disulfiram polymeric nanoparticles (nps) may improve its anticancer activities and protect rapid degradation of the drug. mater...

Poly(vinyl alcohol) and poly(vinyl pyrrolidone) were blended and films were obtained by casting method. Glutaraldehyde, hydrochloric acid and lactic acid were added to investigate their effect on mechanical properties, swelling and solubility of the blends with the aim to find a possible material candidate for medium or long term implants. Combination of all three additives (lactic acid, glutar...

Objective(s): Since microbial contamination can reduce the shelf life of the foodstuff and there is a potential for the growth of some pathogen microorganisms, films containing antimicrobial agents were produced, which are also biodegradable. In this study, the effect of 1, 3 and 5% nano-zinc oxide on antimicrobial properties and permeability of poly lactic acid film was invest...

This article reports experimental data related to the research article entitled "Poly(malic acid-co-l-lactide) as a Superb Degradation Accelerator for Poly(l-lactic acid) at Physiological Conditions" (H.T. Oyama, D. Tanishima, S. Maekawa, 2016) [1]. Hydrolytic degradation of poly(l-lactic acid) (PLLA) blends with poly(aspartic acid-co-l-lactide) (PAL) and poly(malic acid-co-l-lactide) (PML) oli...