نتایج جستجو برای: poloxamer 127

تعداد نتایج: 15382  

Journal: :Drug discoveries & therapeutics 2016
Tanongsak Sassa-Deepaeng Surachai Pikulkaew Siriporn Okonogi

Poloxamer micelles promise safety and efficacy for many water insoluble drugs. Chrysin has been reported to have anticancer, anti-inflammatory, antioxidant, and anti-aromatase activities but its water insoluble properties limit its pharmaceutical application. In the present study, chrysin loaded poloxamer micelles were developed. Two types of poloxamers, Pluronic F-68 and Pluronic F-127 were co...

Journal: :iranian journal of pharmaceutical sciences 0
amal a. elkordy university of sunderland, faculty of applied sciences, department of pharmacy, health and well-being, sunderland, sr1 3sd, uk ebtessam a. essa university of tanta, faculty of pharmacy, egypt

the formulation of hydrophobic drugs for oral drug delivery is challenging due to poor solubility, poor dissolution and poor wetting of these drugs. consequently, the aim of this study was to improve the dissolution of a model poorly water soluble drug, ibuprofen. microparticles containing ibuprofen were produced by spray drying and spray chilling technology in the absence/presence of a hydroph...

Journal: :Drug delivery 2007
D Desai H Zia A Quadir

The primary objective of this study was to compare the lubrication properties of micronized poloxamer 188 (Lmicrotrol micro 68) and micronized poloxamer 407 (Lmicrotrol micro 127) with certain conventional lubricants such as magnesium stearate and stearic acid. The secondary objective was to use these micronized poloxamers as water-soluble tablet lubricants in preparation of effervecsent tablet...

Journal: :JAMA 2001
E P Orringer J F Casella K I Ataga M Koshy P Adams-Graves L Luchtman-Jones T Wun M Watanabe F Shafer A Kutlar M Abboud M Steinberg B Adler P Swerdlow C Terregino S Saccente B Files S Ballas R Brown S Wojtowicz-Praga J M Grindel

CONTEXT Sickle cell disease (SCD) can cause severe painful episodes that are often thought to be caused by vaso-occlusion. The current therapy for these uncomplicated painful episodes includes hydration, oxygen, and analgesics. Purified poloxamer 188 may increase tissue oxygenation and thereby reduce inflammation, pain, and the overall duration of such painful episodes in patients with SCD. O...

2017
Amir Fakhari Marta Corcoran Alexander Schwarz

Poloxamers are triblock copolymers with a center block of hydrophobic polypropylene oxide (PPO) flanked by two hydrophilic polyethyleneoxide (PEO) blocks. Among this family of copolymers, poloxamer 407 is a non-ionic surfactant with reversible gelation properties above a particular polymer concentration and a particular temperature. Easy preparation of poloxamer 407 based sterile injectable for...

Amal Elkordy, Ebtessam Essa

       The formulation of hydrophobic drugs for oral drug delivery is challenging due to poor solubility, poor dissolution and poor wetting of these drugs. Consequently, the aim of this study was to improve the dissolution of a model poorly water soluble drug, ibuprofen. Microparticles containing ibuprofen were produced by spray drying and spray chilling technology in the absence/presence of a ...

2014
Anju Raju A. Jagdeesh Reddy J. Satheesh A. V. Jithan

The objective of this study was to prepare and characterise nevirapine nanosuspensions so as to improve the dissolution rate of nevirapine. Nevirapine is a nonnucleoside reverse transcriptase inhibitor of immunodeficiency virus type-1 and it is poorly water-soluble antiretroviral drug. The low solubility of nevirapine can lead to decreased and variable oral bioavailability. Nanosuspension can o...

2012
Vipin Saxena M Delwar Hussain

BACKGROUND Delivery of a high concentration of anticancer drugs specifically to cancer cells remains the biggest challenge for the treatment of multidrug-resistant cancer. Poloxamers and D-α-Tocopheryl polyethylene glycol 1000 succinate (TPGS) are known inhibitors of P-glycoprotein (P-gp). Mixed micelles prepared from Poloxamer 407 and TPGS may increase the therapeutic efficacy of the drug by d...

2013
D. Ramya Devi

Aim: Poloxamer a block copolymer is well known for its thermoreversible property also has several other properties used in several formulations for its advantage over optimising the drug release from its formulation with a sol-gel transition property. Methods: Poloxamer exhibits in a sol state at less than room temperature and gets converted to a gel state at body temperature (37.2°C) thus modi...

2011
Eun-Kyoung Park

The main objective of this work is to characterize the rheological behavior of poloxamer 407 solutions and gels in various shear flow fields.

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