Recent experimental and modeling studies on the lateral amygdala (LA) have implicated intrinsic excitability and competitive synaptic interactions among principal neurons (PNs) in the formation of auditory fear memories. The present modeling studies, conducted over an expanded range of intrinsic excitability in the network, revealed that only excitable PNs that received tone inputs participate ...

involvement of the peripheral nervous system is one of the complications of multiple myeloma with a varying incidence of clinical and subclinical neuropathy in different studies. as most of the patients with multiple myeloma suffer from generalized systemic symptoms such as malaise, bone and low back pain, the clinical clues to the diagnosis of the neuropathy in its initial stages could be igno...

Lung cancer early detection by low-dose computed tomography (LDCT) can reduce the mortality. However, LDCT increases the number of indeterminate pulmonary nodules (PNs), whereas 95% of the PNs are ultimately false positives. Modalities for specifically distinguishing between malignant and benign PNs are urgently needed. We previously identified a panel of peripheral blood mononucleated cell (PB...

PURPOSE: We aimed to determine whether preoperative nutritional status (PNS) was a valuable predictor of outcome in patients with gastric cancer (GC). METHODS: We retrospectively evaluated 1320 patients with GC undergoing curative resection. The PNS score was constructed based on four objective and easily measurable criteria: prognostic nutritional index (PNI) score 1, serum albumin <35 g/L, bo...

the facial esthetics after orthodontic treatment and orthognathic surgery may be affected by the patient's natural head position. the purpose of this study was to evaluate the natural head position for the three skeletal classes of malocclusion.our sample consisted of 102 lateral cephalometric radiographs of patients aged 15 to 18 years; class i (n=32), class ii (n=40) and class iii (n=30). nin...

Pinostrobin (PNS) belongs to the flavanone subclass of flavonoids which shows several biological activities such as anti-inflammatory, anti-cancerogenic, anti-viral and anti-oxidative effects. Similar to other flavonoids, PNS has a quite low water solubility. The purpose of this work is to improve the solubility and the biological activities of PNS by forming inclusion complexes with β-cyclodex...

Although many years have passed from the recognition of otitis media with effusion (OME), there is much controversy on its etiology, pathogenesis, and treatment strategies. This condition occurs more frequently in infants and children. Moreover, it is more common in Eskimo and Native American than White American and Blacks. In addition, socioeconomic and cultural factors can affect its prevalen...

RATIONALE AND OBJECTIVES The purpose of this study was to assess the impact on times of verification (TOVs) by a pager notification system (PNS) that informs physicians when reports are available for signature. MATERIALS AND METHODS An automated PNS was implemented in the authors' department in November 2000. Monthly report verification times of each physician were collected for 3 months in t...

OBJECTIVES An important subset of patients with schizophrenia present clinically significant persistent negative symptoms (PNS). Identifying the neural substrates of PNS could help improve our understanding and treatment of these symptoms. METHODS This study included 64 non-affective first-episode of psychosis (FEP) patients and 60 healthy controls; 16 patients displayed PNS (i.e., at least o...

PURPOSE Novel panax notoginsenoside-loaded core-shell hybrid liposomal vesicles (PNS-HLV) were developed to resolve the restricted bioavailability of PNS and to enhance its protective effects in vivo on oral administration. METHODS Physicochemical characterizations of PNS-HLV included assessment of morphology, particle size and zeta potential, encapsulation efficiency (EE%), stability and in ...