background: systemic lupus erythematosus (sle) is a chronic autoimmune disease which is characterized by b-cell abnormality and auto-antibody generation. since bacterial infections are the most important causes of mortality in these patients, pneumococcal vaccination is recommended for children with sle. objective: to investigate humoral immunity and specific-antibody formation in response to a...

Background: Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease which is characterized by B-cell abnormality and auto-antibody generation. Since bacterial infections are the most important causes of mortality in these patients, pneumococcal vaccination is recommended for children with SLE. Objective: To investigate humoral immunity and specific-antibody formation in response to a...

Background: Selective antibody deficiency with normal immunoglobulins (SADNI) may be identified as part of distinct primary or secondary immunodeficiency disorders. The clinical manifestations include recurrent, often severe or prolonged, upper or lower respiratory tract infections. Objectives: To evaluate SADNI in patients with recurrent sinopulmonary infections and its relation to IgG subclas...

introduction : streptococcus pneumoniae cause morbidity and mortality in infants and younger children. because of high prevalence of penicillin resistance, rapid and reliable diagnostic techniques for penicillin non-susceptible s. pneumoniae (pnssp) are important for prevention and treatment. we investigated the association of the restriction length polymorphism (rflp) patterns for pbp2b to dis...

background: selective antibody deficiency with normal immunoglobulins (sadni) may be identified as part of distinct primary or secondary immunodeficiency disorders. the clinical manifestations include recurrent, often severe or prolonged, upper or lower respiratory tract infections. objectives: to evaluate sadni in patients with recurrent sinopulmonary infections and its relation to igg subclas...

Background and Objectives: After the introduction of the pneumococcal vaccine, an increase has been observed in the disease due to nonspecific stereotypes of the vaccine. This study was conducted to determine the spatial distribution of pneumococcal vaccine coverage and common stereotypes of streptococcus pneumonia after vaccine introduction in the vaccine recipient countries.   Methods: The ...

Background: Pneumococcal vaccine provides protection against invasive pneumococcal disease in population at risk. This study was conducted to compare the antibody response to 13-valent pneumococcal conjugate vaccine and 23-valent pneumococcal polysaccharide vaccine in patients with thalassemia major. Methods: A randomized cross-over clinical trial was performed on 50 asplenic patients with t...

children under 2 years of age suffer from some of the highest rates of invasive pneumococcal disease (ipd) in the world. (turkey) rates of ipd had a decline after statewide introduction of the 7-valent pneumococcal conjugate vaccine (pcv7) in 2008. introduction of pcv7, pcv10 and pcv13 vaccines resulted in elimination of ipd caused by vaccine serotypes, but was followed by increasing rates of i...