نتایج جستجو برای: plc gene

تعداد نتایج: 1146437  

Journal: :iranian journal of microbiology 0
ali dehghan-noodeh biochemistry department, cambridge system biology centre, university of cambridge, uk. abdulshakor nasir department of life sciences, faculty of science and technology, anglia ruskin university, cambridge, uk. geoff-david robson immunology and microbiology group, faculty of life sciences, university of manchester, manchester, uk.

background and objectives: phosphlipases are a group of enzymes that breakdown phosphatidylcholine (phospholipids) molecules producing second products. these produced products have a divers role in the cell like signal transduction and digestion in humans. in this research the effect of phosphatidylcholine on the expression of plc genes of a. fumigatus was studied. the plc genes of this fungus ...

Journal: :International Heart Journal 2021

Calcium antagonists are used for coronary spastic angina (CSA) treatment. We previously identified a phospholipase C (PLC) -δ1 gene variant that results in enhanced PLC activity patients with CSA and developed animal model by generating vascular smooth muscle cell-specific human PLC-δ1 overexpression (PLC-TG) mice. In this study, we investigated the molecular mechanism of using PLC-TG mice inhi...

2010
Tushi Singal Naranjan S Dhalla Paramjit S Tappia

By employing a pharmacological approach, we have shown that phospholipase C (PLC) activity is involved in the regulation of gene expression of transcription factors such as c-Fos and c-Jun in cardiomyocytes in response to norepinephrine (NE). However, there is no information available regarding the identity of specific PLC isozymes involved in the regulation of c-Fos and c-Jun or on the involve...

Journal: :Journal of bacteriology 1987
R M Ostroff M L Vasil

The phospholipase C (PLC) gene of Pseudomonas aeruginosa encodes a heat-labile secreted hemolysin which is part of a Pi-regulated operon. The structural gene for PLC, plcS, was mutated in vitro by insertion of a tetracycline resistance gene cartridge. Gene replacement techniques were used to introduce the mutated plcS gene into the P. aeruginosa chromosome in place of the wild-type gene. The pr...

Journal: :Infection and immunity 1993
S Daugherty M G Low

Staphylococcus aureus secretes a phosphatidylinositol (PI)-specific phospholipase C (PI-PLC) which is able to hydrolyze the membrane lipid PI and membrane protein anchors containing glycosyl-PI. The gene for PI-PLC (plc) was cloned from S. aureus into Escherichia coli. Oligonucleotide probes based on partial protein sequence and polyclonal antibodies raised against the purified protein were use...

Journal: :Molecular vision 2001
K Shim K M Zavarella C F Thomas R D Shortridge W S Stark

PURPOSE To determine how retinoids regulate the phospholipase C (PLC) gene in the Drosophila visual system. METHODS Western blotting, activity analyses and immunocytochemistry were applied to Drosophila reared on various diets. RESULTS Western blots and activity analyses showed that retinoid deprivation decreases PLC, the product of the norpA gene, by approximately 1/3 to 1/2 in Drosophila....

Journal: :Journal of clinical microbiology 2005
Y Kong M D Cave D Yang L Zhang C F Marrs B Foxman J H Bates F Wilson L N Mukasa Z H Yang

The Mycobacterium tuberculosis genome contains four phospholipase C (PLC)-encoding genes, designated plcA, plcB, plcC, and plcD, respectively. Each of the four genes contributes to the overall PLC activity of M. tuberculosis. PLC is hypothesized to contribute to M. tuberculosis virulence. Infection of M. tuberculosis strains carrying a truncated plcD gene is associated with the occurrence of ex...

SJ Sara

Rats can learn to forage among olfactory cues to associate one with reward in only 3 massed trials. The learning is achieved in less than 10 min and results in a memory trace lasting at least 1wk week. To study the neuro-anatomical circuits involved in the memory formation we used immunoreactivity to the immediate early gene c-fos as a marker for neuronal activity induced by the learning. The p...

Journal: :Fungal genetics and biology : FG & B 2015
Roger R Lew Rachel E Giblon Miranda S H Lorenti

In the filamentous fungus Neurospora crassa, phospholipase C may play a role in hyphal extension at the growing tips as part of a growth-sensing mechanism that activates calcium release from internal stores to mediate continued expansion of the hyphal tip. One candidate for a tip-localized phospholipase C is PLC-1. We characterized morphology and growth characteristics of a knockout mutant (KO ...

Journal: :The Journal of biological chemistry 1991
R D Shortridge J Yoon C R Lending B T Bloomquist M H Perdew W L Pak

A Drosophila phospholipase C (PLC) gene, designated as plc-21, was isolated by screening a genomic DNA library using a cDNA for a previously isolated Drosophila PLC gene, norpA, as probe under reduced stringency hybridization conditions. The gene maps to 21C on the left arm of the second chromosome. Two proteins of 1305 and 1312 amino acids, respectively, were deduced from two classes of cDNA w...

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