نتایج جستجو برای: platinum azidothymidine

تعداد نتایج: 21795  

Journal: :avicenna journal of medical biotechnology 0

background: telomerase activity increases in cancer cells. bcl-2 is an antiapoptotic factor that its concentration grows in many cancer cells including hepatocellular carcinoma cells. in this study, an attempt was made to investigate the effects of a new synthetic compound, platinum azidothymidine (pt-azt) on treatment of rats with hepatocellular carcinoma (hcc) and to compare its effects with ...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1986
P A Furman J A Fyfe M H St Clair K Weinhold J L Rideout G A Freeman S N Lehrman D P Bolognesi S Broder H Mitsuya

The thymidine analog 3'-azido-3'-deoxythymidine (BW A509U, azidothymidine) can inhibit human immunodeficiency virus (HIV) replication effectively in the 50-500 nM range [Mitsuya, H., Weinhold, K. J., Furman, P. A., St. Clair, M. H., Nusinoff-Lehrman, S., Gallo, R. C., Bolognesi, D., Barry, D. W. & Broder, S. (1985) Proc. Natl. Acad. Sci. USA 82, 7096-7100]. In contrast, inhibition of the growth...

2014
Abdolreza Sabokrouh Mohammad Taghi Goodarzi Asad Vaisi-Raygani Shohreh Khatami Masoud Taghizadeh-Jahed

BACKGROUND Telomerase activity increases in cancer cells. Bcl-2 is an antiapoptotic factor that its concentration grows in many cancer cells including hepato-cellular carcinoma cells. In this study, an attempt was made to investigate the effects of a new synthetic compound, platinum azidothymidine (Pt-AZT) on treatment of rats with Hepatocellular Carcinoma (HCC) and to compare its effects with ...

2015
Abdolreza Sabokrouh Asad Vaisi-Raygani Mohammad Taghi Goodarzi Shohreh Khatami Massoud Taghizadeh-jahed Nahid Shahabadi Niknam Lakpour Yadollah Shakiba

BACKGROUND High expression of telomerase and Bcl-2 are reported in hepatocellular carcinoma. Some anticancer drugs show their effects through reduction of these factors. In this study, it was aimed to investigate the effects of a new synthetic compound, platinum azidothymidine, on inhibition of telomerase and Bcl-2 expression in hepatocellular carcinoma compared to azidothymidine. METHODS To ...

Journal: :Postgraduate medical journal 1988
E L Ong M E Ellis D McDowell M Gebril C Weinkove R Ead

A 42 year old heterosexual male with symptomatic human immunodeficiency virus infection presented with a 2-week history of tense blistering skin lesions following azidothymidine therapy. Urinary porphyrin excretion confirmed the diagnosis of porphyria cutanea tarda. The blisters resolved following the withdrawal of the drug but recurred when rechallenged. Three other cases of porphyria cutanea ...

Journal: :Antimicrobial agents and chemotherapy 1989
H König E Behr J Löwer R Kurth

The reverse transcriptase from human immunodeficiency virus type 1 was purified from the virus to near homogeneity. The enzyme was shown to possess both RNA-dependent and DNA-dependent DNA-synthesizing activity. Activated DNA as a heteropolymeric substrate was used as efficiently as was the homopolymeric substrate poly(rA)-oligo(dT). The Michaelis-Menten constants were determined for each of th...

Journal: :International Journal of Radiation Oncology*Biology*Physics 2010

Journal: :The Journal of biological chemistry 1993
C Pidgeon R J Markovich M D Liu T J Holzer R M Novak K A Keyer

Heteroatom fatty acid analogs of myristic acid containing oxygen or sulfur substituted for the alkyl methylene groups inhibit replication of the human immunodeficiency virus (HIV) in infected cells by acting as alternative substrates during the viral protein myristoylation event. In this class of compounds, 12-methoxydodecanoic acid is the most potent compound but is approximately 10(3)-fold le...

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