background: spontaneous abortion is considered as the most complex problem during pregnancy. thrombophilia is resumed as a cause of recurrent pregnancy loss (rpl). glycoprotein iiia (gpiiia) gene is involved in thrombosis and abortion. angiotensin converting enzyme (ace) converts angiotensin i to angiotensin ii and is involved in thrombosis. the most common polymorphism in this gene is the inse...

The topographic relationships of platelet membrane glycoprotein IIb and glycoprotein IIIa have been studied in stimulated and unstimulated human platelets using immunoelectron microscopy. An indirect approach with ferritin-conjugated goat anti-rabbit gamma-globulin was used to localize the rabbit antibody to glycoprotein IIIa. The second ultrastructural label was keyhole limpet hemocyanin conju...

ischemic stroke accounts for about 87 percent of all cases. it occurs as a result of an obstruction within a vessel of the brain and sudden loss of blood circulation to the corresponding area resulting in the loss of brain function. it is caused by thrombotic or embolic occlusion of an artery and is more common than hemorrhagic stroke. we know that most of the injuries after an acute ischemic s...

Ischemic stroke accounts for about 87 percent of all cases. It occurs as a result of an obstruction within a vessel of the brain and sudden loss of blood circulation to the corresponding area resulting in the loss of brain function. It is caused by thrombotic or embolic occlusion of an artery and is more common than hemorrhagic stroke. We know that most of the injuries after an acute ischemic s...

conclusions the authors describe the second reported case of eptifibatide-induced severe thrombocytopenia associated with cardiac surgery. in this case, discontinuation of eptifibatide and transfusion of apheresis platelets increased the platelet count (137 k/ul) the following day, and the patient subsequently underwent successful coronary artery surgery using cardiopulmonary bypass. introducti...

CONTEXT AND OBJECTIVES Glycoprotein inhibitors (abciximab, eptifibatide and tirofiban) are used in patients with unstable angina and non-ST-segment elevation myocardial infarction before percutaneous coronary intervention. Of these, tirofiban is the least effective. We hypothesized that the response to tirofiban might be associated with glycoprotein gene mutations. DESIGN AND SETTING Prospect...

glanzmann's thrombasthenia (gt) is a rare, genetically inherited platelet disorder in which the platelet glycoprotein iib/iiia (gp iib/iiia) complex is either deficient or, dysfunctional. the incidence is about 1 in 1,000,000. this case report deals with a 4 year-old girl diagnosed with gt presenting with dental caries and periapical lesions in the primary mandibular first molars. to provide th...

Abciximab (Abci) and eptifibatide (Epti) are antiaggregate drugs which may reduce thrombotic complications in acute coronary syndromes. The aim of this work was the investigation of the interaction between the phospholipid-GPIIb/IIIa glycoprotein complex and Abci or Epti, and the influence of these drugs on the phospholipid ratio in the platelet membrane. The interaction between the phospholipi...