نتایج جستجو برای: plasminogen deficiency

تعداد نتایج: 153727  

Journal: :journal of current ophthalmology 0
محمد زارع mohammad zare محمدرضا فلاح تفتی mohammadreza fallah tafti فاطمه زارع fateme zare بهرام اشراقی bahram eshraghi فهیمه اسدی آملی fahimeh asadi amoli محمدیاسر کیلرودی mohammad yaser kiarudi

purpose : to report an association of ligneous conjunctivitis (lc) and congenital hydrocephalus case report : the patient was a 3.5-year-old boy with a history of long standing conjunctivitis with copious ocular discharge and photophobia, waxing and waning for some time. he also had suffered from occlusive congenital hydrocephalus that required placement of a ventriculoperitoneal shunt. conjunc...

Journal: :Haemophilia 2008

Journal: :Haemophilia : the official journal of the World Federation of Hemophilia 2008
R Mehta A D Shapiro

Plasminogen deficiency has emerged as a well-recognized disorder in which reduced levels of plasminogen lead to the development of pseudo membranes on mucosal surfaces, with subsequent end-organ damage of the affected tissue. Ligneous conjunctivitis is the most recognizable, well-documented, and common presentation of the clinical syndromes associated with plasminogen deficiency, although numer...

2016
Laura Martin-Fernandez Pascual Marco Irene Corrales Raquel Pérez Lorena Ramírez Sonia López Francisco Vidal José Manuel Soria

Although plasminogen is a key protein in fibrinolysis and several mutations in the plasminogen gene (PLG) have been identified that result in plasminogen deficiency, there are conflicting reports to associate it with the risk of thrombosis. Our aim was to unravel the genetic architecture of PLG in families with plasminogen deficiency and its relationship with spontaneous thrombotic events in th...

Journal: :The Journal of Experimental Medicine 1997
A. Richard Kitching Stephen R. Holdsworth Victoria A. Ploplis Edward F. Plow Désiré Collen Peter Carmeliet Peter G. Tipping

The plasminogen/plasmin system has the potential to affect the outcome of inflammatory diseases by regulating accumulation of fibrin and other matrix proteins. In human and experimental crescentic glomerulonephritis (GN), fibrin is an important mediator of glomerular injury and renal impairment. Glomerular deposition of matrix proteins is a feature of progressive disease. To study the role of p...

Journal: :Blood 1998
A F Drew A H Kaufman K W Kombrinck M J Danton C C Daugherty J L Degen T H Bugge

Ligneous conjunctivitis is a rare form of chronic pseudomembranous conjunctivitis that is associated with systemic membranous pathological changes. A probable link between plasminogen and ligneous conjunctivitis has been indicated by the recent diagnoses of plasminogen deficiency in five patients suffering from ligneous conjunctivitis. The current study reports that plasminogen-deficient mice d...

Journal: :The Journal of clinical investigation 1986
L A Miles M H Ginsberg J G White E F Plow

Glu-plasminogen, the native form of plasminogen, interacts in a specific and saturable manner with unstimulated human platelets, and the binding is enhanced fivefold by thrombin stimulation (Miles and Plow, 1985. J. Biol. Chem. 260:4303). This study characterizes the nature of the Glu-plasminogen binding sites by analyzing platelets deficient in selected proteins and functions. Platelets from p...

Journal: :The Journal of clinical investigation 2000
N Hattori J L Degen T H Sisson H Liu B B Moore R G Pandrangi R H Simon A F Drew

Mice deleted for the plasminogen activator inhibitor-1 (PAI-1) gene are relatively protected from developing pulmonary fibrosis induced by bleomycin. We hypothesized that PAI-1 deficiency reduces fibrosis by promoting plasminogen activation and accelerating the clearance of fibrin matrices that accumulate within the damaged lung. In support of this hypothesis, we found that the lungs of PAI-1(-...

Journal: :The Journal of biological chemistry 2002
Sarah Netzel-Arnett David J Mitola Susan S Yamada Kali Chrysovergis Kenn Holmbeck Henning Birkedal-Hansen Thomas H Bugge

Matrix metalloproteinase-14 is required for degradation of fibrillar collagen by mesenchymal cells. Here we show that keratinocytes use an alternative plasminogen and matrix metalloproteinase-13-dependent pathway for dissolution of collagen fibrils. Primary keratinocytes displayed an absolute requirement for serum to dissolve collagen. Dissolution of collagen was abolished in plasminogen-deplet...

Journal: :Stroke 1991
H S Schutta E C Williams B G Baranski T P Sutula

We describe a patient with inherited plasminogen deficiency who developed extensive cerebral venous thrombosis. Several other conditions that might have contributed to a hypercoagulable state, including mild thrombocytosis, thyrotoxicosis, and a chronic inflammatory lung disorder, were present. We also discuss the evidence linking plasminogen deficiency with a thrombophilic state. The diagnosis...

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