نتایج جستجو برای: pl2l60
تعداد نتایج: 4 فیلتر نتایج به سال:
PIWIL2-like (PL2L) protein 60 (PL2L60), a product of aberrantly activated PIWIL2 gene, is widely expressed in various types of tumors and may promote tumorigenesis. However, the mechanisms underlying the activation of expression of PL2L60 remain unknown. In this study, an intragenic promoter responsible for the activation of PL2L60 within the human PIWIL2 gene has been identified, cloned and ch...
PIWIL2, a member of PIWI/AGO gene family, is expressed in the germline stem cells (GSCs) of testis for gametogenesis but not in adult somatic and stem cells. It has been implicated to play an important role in tumor development. We have previously reported that precancerous stem cells (pCSCs) constitutively express Piwil2 transcripts to promote their proliferation. Here we show that these trans...
background: cancer/testis antigens (ctas) are members of a group of proteins which are normally expressed in testis germ cells and to a lesser extent in the ovaries. because of recent reports about their aberrant and specific expression in some tumoral tissues, they may play a role as new candidates for targeted therapy. therefore, the study of the expression pattern of these biomarkers and its...
چکیده مقدمه : سرطان پستان شایعترین سرطان در بین زنان و دومین عامل مرگ ومیر زنان بعد از سرطان ریه به شمار میرود.بیومارکرهایی که در بافت سرطانی بیان میشوند نقش مهمی درتشخیص،پیش آگهی و پاسخ به درمان دارند.محققان همواره به دنبال ژنهایی هستند که به طوراختصاصی دربافت سرطان بیان شود.ژنهای سرطانی- بیضه ای از جمله ژنهایی هستند که اخیرا ادعامی شود که علاوه بر بافت بیضه منحصرادربعضی بافتهای سرطانی بیان ...
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