نتایج جستجو برای: piroctone olamine

تعداد نتایج: 105  

2010
Hosein Rastegar Ramin Khanmohammad

Background: Dandruff especially with itching and inflammation is a common complaint among patients in the clinic and its treatment is much challenging. Chemical anti fungal substances used in antidandruff shampoos are common treatments. The aim of this study was to compare the clinical efficacy of two of these anti dandruff substances, climbazole and piroctone olamine in the treatment of dandru...

Journal: :SpringerPlus 2016
Fabíola Maria Marques do Couto Silene Carneiro do Nascimento Silvio Francisco Pereira Júnior Vanessa Karina Alves da Silva André Ferraz Goiana Leal Rejane Pereira Neves

This work aimed to evaluate the antifungal activity of piroctone olamine in the treatment of intra-abdominal candidiasis in an experimental model using Swiss mice. The mice (n = 6) were infected by intraperitoneal injection of 0.2 ml of C. albicans (10(7)cells/ml in saline). The animals were observed daily for clinical signs and mortality for 14 days. The treatment with piroctone olamine (0.5 m...

Ashtiani Hamidreza Ahmadi Azizahari Sahar Baghaei Mohammad Bokaei Saeid Ehsani Amirhoushang hanmohammad Ramin Noormohammadpour Pedram Rastegar Hosein

Background: Dandruff especially with itching and inflammation is a common complaint among patients in the clinic and its treatment is much challenging. Chemical anti fungal substances used in antidandruff shampoos are common treatments. The aim of this study was to compare the clinical efficacy of two of these anti dandruff substances, climbazole and piroctone olamine in the treatment of dandru...

Journal: :In vivo 2011
Young Kim Petra Alpmann Sabine Blaum-Feder Simon Krämer Tomoyuki Endo Desheng Lu Dennis Carson Ingo G H Schmidt-Wolf

BACKGROUND It was recently confirmed that the antifungal agent ciclopirox olamine inhibits Wnt/beta catenin signaling in myeloma. Piroctone olamine (PO) has very similar chemical features to ciclopirox olamine. MATERIALS AND METHODS This study investigated the antitumor effect of PO in vitro and in vivo in a murine myeloma model. RESULTS PO demonstrated a major apoptotic activity in various...

2016
Hae Jeong Youn Soo Young Kim Minji Park Won Hee Jung Yang Won Lee Yong Beom Choe Kyu Joong Ahn

BACKGROUND Seborrheic dermatitis (SD) is a multifactorial disease; Malassezia species play an important role in its pathogenesis. OBJECTIVE We aimed to determine whether a cream containing climbazole/piroctone olamine (C/P cream), antifungal agents with expected efficacy against Malassezia species, could improve SD symptoms. METHODS We instructed 24 patients with mild-to-moderate SD to appl...

Journal: :Molecular pharmacology 2015
Viktoryia Sidarovich Valentina Adami Pamela Gatto Valentina Greco Toma Tebaldi Gian Paolo Tonini Alessandro Quattrone

Iron is an essential cellular nutrient, being a critical cofactor of several proteins involved in cell growth and replication. Compared with normal cells, neoplastic cells have been shown to require a greater amount of iron, thus laying the basis for the promising anticancer activity of iron chelators. In this work, we evaluated the effects of molecules with iron chelation activity on neuroblas...

Journal: :Anticancer research 2014
Sarah Annette VON Schulz-Hausmann Leonard Christopher Schmeel Frederic Carsten Schmeel Ingo G H Schmidt-Wolf

BACKGROUND/AIM Advanced renal cancer still has a very poor prognosis. In this regard recent investigations demonstrated a constitutive activation of the Wnt signaling pathway in renal cell carcinoma (RCC) thereby promoting an exaggerated cell proliferation. Especially, β-catenin overactivation and the functional loss of endogenous Wnt antagonists are associated with RCC carcinogenesis and progr...

Journal: :Anais brasileiros de dermatologia 2011
Cibele Massotti Magagnin Cheila Denise Ottonelli Stopiglia Fabiane Jamono Vieira Daiane Heidrich Madeline Machado Gerson Vetoratto Flávia Maria Lamb Maria Lúcia Scroferneker

BACKGROUND The prevalence of dermatophytosis in the general population is high, particularly in patients with chronic renal failure. Treatment requires the use of topical and/or systemic antifungal drugs. The efficacy of antifungal agents for the treatment of dermatophytosis has yet to be evaluated. Studies evaluating the in vitro activity of antifungal agents are rare, particularly in filament...

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