WINTER, J. C., R. A. FILIPINK, D. TIMINERI, S. E. HELSLEY AND R. A. RABIN. The paradox of 5-methoxyN,N -dimethyltryptamine: An indoleamine hallucinogen that induces stimulus control via 5-HT 1 A receptors . PHARMACOL BIOCHEM BEHAV 65 (1) 75–82, 2000.—Stimulus control was established in rats trained to discriminate either 5-methoxyN,N -dimethyltryptamine (3 mg/kg) or ( 2 )-2,5-dimethoxy-4-methyl...

In the present study, the effect of 5-HT2A receptor blockers in CA1 region of rat hippocampus on spatial learning was assessed in a T-maze, a spatial discrimination task. Rats were canulated bilaterally and injected daily vehicle (saline), 5-HT2A-selective antagonist, ketanserin (0.6, 1.2 or 2.4 µg/0.5 µl) and pirenperone (0.1, 0.3, 1.2 or 2.4 µg/0.5 µl) into the cannula 30 minutes before train...

Elucidating the mechanisms of action of hallucinogens has become an increasingly important area of research as their abuse has grown in recent years. Although serotonin receptors appear to play a role in the behavioral effects of the phenethylamine and indoleamine hallucinogens, the signaling pathways activated by these agents are unclear. Here it is shown that administration of serotonin (5-hy...

in the present study, the effect of 5-ht2a receptor blockers in ca1 region of rat hippocampus on spatial learning was assessed in a t-maze, a spatial discrimination task. rats were canulated bilaterally and injected daily vehicle (saline), 5-ht2a-selective antagonist, ketanserin (0.6, 1.2 or 2.4 µg/0.5 µl) and pirenperone (0.1, 0.3, 1.2 or 2.4 µg/0.5 µl) into the cannula 30 minutes before train...

in this study the effects of 5-ht2a receptor blockers in ca1 region of rat hippocampus on spatial learning were assessed in a t-maze, a spatial discrimination task. rats were connulated and bilateral injection of vehicle (saline) and 5-ht2a- selective antagonist, ketanserin (0.6, 1.2 or 2.4 µg/0.5 µl) were injected through the connulae 30 miutes before training each day. results indicated that ...

Previous research in our laboratory suggests that serotonin (5-HT) neurotransmission mediates the expression of cocaine-induced convulsions. The role of 5-HT in mediating this toxic effect of cocaine appears to be due to activation of 5-HT(2) receptors, because cocaine-induced convulsions are blocked by the 5-HT(2) antagonists cinanserin, ketanserin, and pirenperone. The present study utilized ...