The PINCH-1-integrin-linked kinase (ILK)-alpha-parvin (PIP) complex plays important roles in the regulation of glomerular cell behavior, including podocyte shape change, apoptosis, and mesangial fibronectin matrix deposition. In this study, we show that PINCH-2, a protein that is structurally related to PINCH-1 but encoded by a different gene, is coexpressed with PINCH-1 in podocytes. Treatment...

OBJECTIVE To examine the intra-rater, inter-rater, and inter-instrumental reliability of the digitalized pinch muscle strength dynamometer. METHOD Thirty normal subjects were examined for pinch strength, using both the Preston pinch gauge and the digitalized pinch dynamometer. The participants performed all pinch strength tests in the seated position as recommended by the American Society of ...

This paper describes the use of a neonatal sphygmomanometer cuff as a simple, inexpensive pinch meter. Normal values for key pinch, pulp pinch and side pinch in the dominant hand of healthy Nepali people are provided. The pinch meter was also used to test pinch strength in hands affected by leprosy and normal hands. Some patients with leprosy who have no objective weakness on voluntary muscle t...

BACKGROUND Data on the physical strength capabilities are essential for designing safe and usable products and are useful in a wide range of clinical settings especially during treatment of disease affecting the function of the hand. The purpose of this study was to determine peak lateral pinch strength, key pinch strength, tip-to-tip pinch strength and three-jaw pinch strength exertions in a h...

Repetitive, high-force pinch grip exertions are common in many occupational activities. The goal of the current study was to quantify the relationship between lateral pinch grip span (distance between thumb and index finger) and lateral pinch grip strength. An experiment was conducted in which 40 participants performed maximal lateral pinch grip exertions at 11 levels of grip span distances (0,...

measuring and comparing grip and pinch strengths with their normative data is a valid method to detect intensity of the numerous damages of hand. this research was carried out with the aim of establishing normative data of grip strength and three types of pinch strengths (tip, key and palmar) in healthy iranian adults.in this cross-sectional study, the study population was formed of 1008 people...

PINCH, integrin-linked kinase (ILK) and Ras suppressor-1 (RSU-1) are molecular scaffolding proteins that form a physical complex downstream of integrins, and have overlapping roles in cellular adhesion. In Drosophila, PINCH and ILK colocalize in cells and have indistinguishable functions in maintaining wing adhesion and integrin to actin linkage in the muscle. We sought to determine whether the...

results grip strength and tip and palmer pinch strength in dominant side were statistically greater than them in nondominant side (p < 0.05). there were significant associations between grip strength and height (r = 0.33, p < 0.001), body mass (r = 0.50, p < 0.001), bmi (r = 0.37, p < 0.001), muscle mass of upper extremity (r = 0.56, p < 0.001), fat free mass (r = 0.57, p < 0.001), fat mass (r ...

Particularly interesting Cys-His-rich protein (PINCH) has several biological functions in cancer development, invasion and metastasis in malignant cells, and the expression of PINCH is upregulated in several cancer types, including breast cancer, gastric adenocarcinoma and rectal cancer. However, the contribution of PINCH to human cerebral aneurysms remains largely unknown. Therefore, the signi...