The pathway of oxidation of picolinamide (pyridine-2-carboxamide) by a Gram-negative rod has been elucidated. Under conditions of high pH, restricted aeration and high substrate concentration, whole cells released 2,5-dihydroxypyridine into culture supernatants. Sodium arsenite at 5mm caused whole cells to accumulate 6-hydroxypicolinate, and, at 1mm, pyruvate, in culture media. Whole cells oxid...

The title compound, [Na2(C6H5N2O2)2(C6H6N2O2)4], is a centrosymmetric coordination dimer based on the sodium(I) salt of N-hy-droxy-picolinamide. The mol-ecule has an {Na2O6(μ-O)2} core with two bridging carbonyl O atoms and two hydroxamate O atoms of two mono-deprotonated residues of N-hy-droxy-picolinamide, while two neutral N-hy-droxy-picolinamide mol-ecules are coordinated in a monodentate m...

Metal-ion mediated reactions of 2-pyridinealdoxime and hexafluorophosphate lead to Zn(II) complexes containing picolinic acid, picolinamide and monofluorophosphate (-2) as ligands.

We report a new synthesis of phenanthridines based on palladium-catalyzed picolinamide-directed sequential C-H functionalization reactions starting from readily available benzylamine and aryl iodide precursors. Under the catalysis of Pd(OAc)2, the ortho-C-H bond of benzylpicolinamides is first arylated with an aryl iodide. The resulting biaryl compound is then subjected to palladium-catalyzed p...

In the title mol-ecule, C(8)H(9)N(3)O(4), the amide group is involved in the formation of an intra-molecular N-H⋯N hydrogen bond. In the crystal, mol-ecules related by translation along the a axis are linked into chains via weak inter-molecular C-H⋯O inter-actions.

Although there is evidence for the anti-inflammatory activity of nicotinamide, there is no evaluation of its effects in models of nociceptive and inflammatory pain. In addition, there is no information about the potential anti-inflammatory and antinociceptive activities of the nicotinamide isomers, picolinamide and isonicotinamide. Per os (p.o.) administration of nicotinamide (1000 mg/kg, -1h) ...

A removable bidentate picolinamide assisted regioselective 1,2-carbosulfenylation of unactivated alkenes with aryl/alkenylboronic acids and disulfide electrophiles has been developed a cost-effective air-stable Ni( ii ) precatalyst.

The crystal structure of the title compound, C6H6N2O2·H2O, consists of N-hy-droxy-picolinamide and water mol-ecules connected through O-H⋯O and N-H⋯N hydrogen bonds. The O-H⋯O inter-actions and π-π stacking inter-actions between the pyridine rings [centroid-centroid distance = 3.427 (1) Å] organize the components into columns extending along the b axis and the N-H⋯N hydrogen bonds link these co...

The title compound, [Ni(N(3))(2)(C(6)H(6)N(2)O)(2)], was obtained as the first crystalline product from the reaction of Ni(NO(3))(2)·6H(2)O, picolinamide and NaN(3) in aqueous media. After a few days in the mother liquor, crystals of the cis isomer transformed into the trans isomer [Đaković & Popović (2007 ▶). Acta Cryst. C63, m507-m509]. The Ni atom exhibits a distorted octa-hedral environment...