delivery of exogenous materials such as nucleic acids, peptides, proteins, and drugs into cells is an important strategy in modern cellular and molecular biology. recently, the development of gene carriers for efficient gene transfer into cells has attracted a great attention. furthermore, lack of effective drug delivery is one of the major problems of cancer chemotherapy. many physical methods...

Performance on the Sternberg working memory task, and MEG cortical response on a variation of the Sternberg task were examined in middle-aged carriers and non-carriers of the APOE epsilon4 allele. Physical activity was also assessed to examine whether exercise level modifies the relationship between APOE genotype and neurocognitive function. Regression revealed that high physical activity was a...

carbamazepine belongs to the class ii biopharmaceutical classification system (bcs) which is characterized by a high per-oral dose, a low aqueous solubility and a high membrane permeability. the bioavailability of such a drug is limited by the dissolution rate. in order to increase the drug dissolution, its solid dispersions were prepared by the cogrinding technique using an insoluble but highl...

Title of Document: THE RELATIONSHIP BETWEEN PHYSICAL ACTIVITY AND EXECUTIVE CONTROL FUNCTIONING AS MODIFIED BY GENOTYPE Joe W. Hearn, Master of Arts, 2007 Directed By: Professor Bradley D. Hatfield Department of Kinesiology As we age, the structure of the brain deteriorates and cognitive functioning declines. The region of the brain that begins to age the fastest is the frontal lobe, in which t...

Carbamazepine belongs to the class II biopharmaceutical classification system (BCS) which is characterized by a high per-oral dose, a low aqueous solubility and a high membrane permeability. The bioavailability of such a drug is limited by the dissolution rate. In order to increase the drug dissolution, its solid dispersions were prepared by the cogrinding technique using an insoluble but highl...

Carbamazepine belongs to the class II biopharmaceutical classification system (BCS) which is characterized by a high per-oral dose, a low aqueous solubility and a high membrane permeability. The bioavailability of such a drug is limited by the dissolution rate. In order to increase the drug dissolution, its solid dispersions were prepared by the cogrinding technique using an insoluble but highl...