background: as bremsstrahlung photon beam fluence is important parameter to be known in a photonuclear reaction experiment as the number of produced particle is strongly depends on photon fluence. materials and methods: photon production yield from different thickness of aluminum target has been estimated using artificial neural network (ann) model. target thickness and incoming electron energy...

Background: As bremsstrahlung photon beam fluence is important parameter to be known in a photonuclear reaction experiment as the number of produced particle is strongly depends on photon fluence. Materials and Methods: Photon production yield from different thickness of aluminum target has been estimated using artificial neural network (ANN) model. Target thickness and incoming electr...

Background: The aim of present study was to analyze the effectiveness of electron filters in the Telecobalt radiotherapy treatment by simulation technique.  Materials and Methods: The BEAMnrc Monte Carlo code was used to simulate the electron filters of thickness of 0.5 gm/cm2 below the trimmer bar for 35 × 35 cm2 field size in Theratron Equinox-80 telecobalt unit. The electron filters were mad...

In order to better understand light dosimetry issues for photodynamic therapy (PDT), we have used various tumor and normal tissue geometries to develop a diffusion model of light transport in tissues. We hypothesize that tumor tissues with curved surfaces will have significantly different internal fluence distributions, as compared to tissues with flat surfaces. Using a mouse subcutaneous tumor...

Introduction: Physical wedge as a useful tool has been utilized in radiotherapy to modify photon beam shape and intensity such that it distributes dose uniformly in tumor site and reduces hot points. Since during Linac commissioning dosimetric parameters like output factors and lateral dose profiles are measured only for symmetric open and wedged fields, so calculation the par...

A method to smooth intensity-modulated photon beams is presented which can be applied in conjunction with any optimization algorithm. The method employs an additional soft constraint to minimize the area of the surface defined by the photon fluence.

Arabidopsis thaliana seeds imbibed for a short duration show phytochrome B (PhyB)-specific photo-induction of germination. Using this system, the relationship was determined between the amount of PhyB in seeds and photon energy required for PhyB-specific germination in two transgenic Arabidopsis lines transformed with either the Arabidopsis PhyB cDNA (ABO) or the rice PhyB cDNA (RBO). Immunoche...

This work presents a numerical study of the fluence-resolution behaviour for two coherent lensless X-ray imaging techniques. To this end the fluence-resolution relationship of inline near-field holography and far-field coherent diffractive imaging are compared in numerical experiments. To achieve this, the phase reconstruction is carried out using iterative phase-retrieval algorithms on simulat...

The response of human glioma spheroids to 5-aminolevulinic acid (ALA)-mediated photodynamic therapy (PDT) is investigated. A two-photon fluorescence microscopy technique is used to show that human glioma cells readily convert ALA to protoporphyrin IX throughout the entire spheroid volume. The central finding of this study is that the response of human glioma spheroids to ALA-mediated PDT depend...