background: drug delivery systems related to different cancer therapy is now expanding. chitosan (cs) is currently receiving enormous interest for medical and pharmaceutical applications due to its biocompatibility in animal tissues. in this study two nanogels were prepared from chitosan. some of the critical factors such as controlling the release, adsorption and specially targeting drug deliv...

Two natural macromolecules, chitosan and ovalbumin, were used to produce nanogels by a new, green, and convenient method. Chitosan and ovalbumin solutions were mixed; the pH of the resulting solution was adjusted; and the solution was successively stirred and heated. After that, ovalbumin gelled forming nanospheres. The chitosan chains are supposed to be partly trapped in the nanogel core upon ...

Chitosan-based nanogels have been widely applied as drug delivery vehicles. Spray-drying of said nanogels allows for the preparation of dry powder nano-embedded microparticles. In this work, chitosan-based nanogels composed of chitosan, alginate, and/or sodium tri-penta phosphate were investigated, particularly with respect to the impact of composition on the resulting physicochemical propertie...

Macrophages play key roles in inflammatory disorders. Therefore, they are targets of treatments aiming at their local destruction in inflammation sites. However, injection of low molecular mass therapeutics, including photosensitizers, in inflamed joints results in their rapid efflux out of the joints, and poor therapeutic index. To improve selective uptake and increase retention of therapeutic...

Glycol chitosan nanogels have been widely used in gene, drug, and contrast agent delivery in an effort to improve disease diagnosis and treatment. Herein, we evaluate the internalization mechanisms and intracellular fate of previously described glycol chitosan nanogels decorated with folate to target the folate receptor. Uptake of the folate-decorated nanogel was impaired by free folate, sugges...

Thermo-gelling injectable nanogels, with no burst release of loaded drug, were prepared by a simple route by combining self assembled nanocapsules of amphiphilically modified chitosan with glycerophosphate di-sodium salt and glycerol. The potential as a depot drug delivery system was demonstrated in vivo through the therapeutic effect of ethosuximide (ESM) loaded nanogels, suppressing spike wav...

Chitosan was prepared from crab shell. Different derivatives of chitosan e.g. phosphate, cyanoethyl and carboxymethyl chitosan are prepared. Molecular structure of chitosan and its derivatives was fallowed by infrared spectroscopy. A new band at 1715cm -1 (carboxyl group), at 2253cm -1 (cyano group) and at 1200cm -1 for (c-o-p) in spectra of carboxymethyl chitosan, cyanoethyl chitosan and chito...

Many studies have tried to look for the application of chitosan in tissue engineering since its structure is similar to glycoaminoglycans, the main components of the extracellular matrix. Previous studies had indicated that the incorporation of sulfonic or phosphonic functionalities would be beneficial to the growth of certain cells. However, no study has explored the effect of incorporation o...

Nanogels of a binary system of carboxymethyl chitosan (CMCh) and poly- (vinyl alcohol) PVA, were successfully synthesized by a novel in situ process. They were also characterized by various analytical tools like Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM) and X-ray diffraction (XRD). They were studied for their unique swelling properties in water and d...